JaLCDOI 10.18926/AMO/32678
FullText URL fulltext.pdf
Author Sakagami, Kenichi| Saito, Shinya| Shiozaki, Shigehiro| Fujiwara, Takuzo| Haisa, Minoru| Niguma, Takefumi| Kusaka, Satoshi| Uda, Masashi| Matsuno, Tsuyoshi| Takasu, Shinji| Yerdel, Mehmet Ali| Matsuoka, Junji| Tanaka, Shinichiro| Orita, Kunzo|
Abstract <p>One-hundred-nine HLA-haploidentical living related renal transplants have been retrospectively analysed to compare the effect of donor-specific blood transfusion (DST) and different immunosuppressive regimens on graft survival and acute rejection. The recipients were divided into four groups according to the immunosuppressive therapy. Group 1 (n = 44): conventional therapy with posttransplant azathioprine (AZP) + methylprednisolone (MP). Group 2 (n = 25): pretransplant DST + posttransplant AZP + MP. Group 3 (n = 12): triple-drug therapy with posttransplant AZP + MP + cyclosporine (CS). Group 4 (n = 25): pretransplant DST + posttransplant AZP + MP + CS. The five-year actuarial survival rates for groups 1, 2, 3 and 4 were 48%, 73%, 79%, and 89%, respectively. The graft survival rate in group 3 was significantly (p less than 0.01) better than that in group 1. The transfusion effect was reduced, and appears as a 10% improvement in the graft survival in the cyclosporin era compared with a 25% improvement at pre-cyclosporin era. Furthermore, the incidence of the first rejection episode was decreased in recipients that received DST. The present study revealed that DST, as pretransplant conditioning has a definite impact on rejection-free long-term graft survival in HLA-haploidentical living-related kidney recipients and the most favorable outcome in such patients could be achieved by DST pretreatment in conjunction with posttransplant triple-drug therapy including cyclosporine.</p>
Keywords living-related kindney transplantation donor-specific blood transfusion (DST) cyclosporine
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 5
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561899
Web of Sience KeyUT A1992HH01700001
JaLCDOI 10.18926/AMO/32032
FullText URL fulltext.pdf
Author Noguchi, Hirofumi| Naomoto, Yoshio| Haisa, Minoru| Yamatsuji, Tomoki| Shigemitsu, Kaori| Uetsuka, Hirokazu| Hamasaki, Shuji| Tanaka, Noriaki|
Abstract <p>A 60-year-old man was admitted to our hospital with a right inguinal swelling that had been growing in size without any pain for 7 months. We diagnosed the growth as a right inguinal hernia and operated on him. The growth, however, was found to be a tumor it situated along the spermatic cord and testicular vessels. We diagnosed it as a lipoma. The tumor was resected near part of the internal inguinal ring. Histopathological diagnosis showed well-differentiated liposarcoma of the sclerosing type. Postoperative computed tomography (CT) revealed a large residual tumor in the retroperitoneum. We believed that the tumor was a retroperitoneal liposarcoma and that it developed in the inguinal region. The residue of the liposarcoma was resected onto the right inguinal tract. A periodic follow up has been performed and no evidence of recurrence or metastasis has been seen in the 4 years and 9 months since the second surgery. No adjuvant therapy was performed. Inguinal liposarcomas are relatively rare and in most cases these tumors are thought to originate in the spermatic cord. The origin of the tumor is believed to be the retroperitoneum</p>
Keywords liposarcoma retroperitoneum inguinal hernia
Amo Type Article
Published Date 2001-02
Publication Title Acta Medica Okayama
Volume volume55
Issue issue1
Publisher Okayama University Medical School
Start Page 51
End Page 54
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11246977
Web of Sience KeyUT 000167249900007