JaLCDOI 10.18926/AMO/32861
FullText URL fulltext.pdf
Author Ashizawa, Tatsuto| Iwahori, Tohru| Yokoyama, Takayoshi| Kihara, Yuu| Konnno, Osamu| Jyojima, Yoshimaro| Akashi, Isao| Nakamura, Yuuki| Hama, Kouichirou| Iwamoto, Hitoshi| Segawa, Mai| Takeuchi, Hironori| Hirano, Toshihiko| Nagao, Takeshi|
Abstract <p>We investigated changes in drug disposition and toxicities with CPT-11 in 15 dialysis patients with gastrointestinal cancers to clarify whether CPT-11 could be administered safely in such patients. For comparison, the same parameters were also investigated in 10 cancer patients not undergoing dialysis. Items investigated included (1) plasma concentrations of SN-38, SN-38G and CPT-11 at 0, 1, 12, 24, 36, 48 and 72h after administration, together with a comparison of mean AUC values for 3 dose levels of CPT-11 (50, 60 and 70mg/m2) in dialysis patients and controls;and (2) occurrence of adverse events. Several findings emerged from this study:(1) No significant difference was observed in the AUC for SN-38 or CPT-11 between the dialysis and control groups;(2) The AUC for SN-38G at each dose was significantly higher in dialysis patients;and (3) Grade 1-4 leucopenia was observed in 11 of the dialysis patients. One patient developed grade 4 leucopenia and died due to sepsis. Anorexia, diarrhea, nausea, alopecia and interstitial pneumonia occurred in 6 dialysis patients. We found changes in drug dispositions of CPT-11, SN-38 and SN-38G in dialysis patients, suggesting that hepatic excretion, especially that of SN-38G, was increased. No significant difference in occurrence of adverse events was observed between the 2 groups. This indicates that CPT-11 can be administered safely in patients on dialysis.</p>
Keywords irinotecan hydrochloride (CPT-11) chronic kidney disease (CKD) end-stage renal disease (ESRD) dialysis colorectal cancer
Amo Type Original Article
Published Date 2010-02
Publication Title Acta Medica Okayama
Volume volume64
Issue issue1
Publisher Okayama University Medical School
Start Page 19
End Page 26
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 20200580
Web of Sience KeyUT 000274868300003