JaLCDOI 10.18926/AMO/32207
FullText URL fulltext.pdf
Author Okada, Soji| Ichiki, Ken| Sato, Kimiaki| Tanakuchi, So| Ishii, Keita| Hamada, Hiroshi| Ota, Zensuke|
Abstract <p>We studied the pathways of complement activation associated with the islet cell surface antibody (ICSA) obtained from sera of 7 patients (age less than 15 years) with insulin dependent diabetes mellitus (IDDM). The target cells were 51CR labelled rat islet cells and the complement source was human AB serum. Complement-dependent antibody mediated cytotoxicity (CAMC activity) was obtained using the percentage of cytotoxicity. CAMC activity of untreated sera was significantly inhibited by treating with EGTA or EDTA (p less than 0.001). The CAMC activity of EDTA-treated sera was significantly lower than that of EGTA-treated sera (p less than 0.001). In the inactivated human AB serum, it was lower than that of EGTA-treated sera (p less than 0.05), but not different from that of EDTA-treated sera. These results show that the complement activation associated with ICSA in patients occurred not only via the classical pathway but also via the alternative pathway.</p>
Keywords complement activation islet surface antibody insulin-dependent diabetes mellitus complement-dependent antibody medeated cytotoxicity classical pathway alternative pathway
Amo Type Article
Published Date 1991-06
Publication Title Acta Medica Okayama
Volume volume45
Issue issue3
Publisher Okayama University Medical School
Start Page 185
End Page 186
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1909828
Web of Sience KeyUT A1991FV15000009
JaLCDOI 10.18926/AMO/32670
FullText URL fulltext.pdf
Author Okada, Soji| Tanokuchi, So| Ichiki, Ken| Ishii, Keita| Hamada, Hiroshi| Ota, Zensuke|
Abstract <p>To evaluate urinary albumin index (UAI), the relationship between albumin excretion rate (AER) in the urine stored for 24 h and UAI in the urine collected arbitrarily on the morning of the same day was studied in 123 inpatients. The patients were admitted to our hospital from September 1, 1988 to August 31, 1989, consisting of 67 non-insulin dependent diabetics (Group 1), 40 patients with collagen disease (Group 2), and 16 patients with primary renal disease (Group 3). The relationship between log(e) AER and log(e)UAI was plotted on a graph. Pearson's rank correlation coefficients of Groups 1-3, Group 1, Group 2, and Group 3 were as follows: r = 0.725, r = 0.691, r = 0.855, and r = 0.611, respectively. The formula obtained by using Pearson's rank correlation coefficients to estimate log(e)AER from log(e)UAI in 123 cases of Groups 1-3, 67 cases of Group 1, 40 cases of Group 2, and 16 cases of Group 3 were: log(e)AER/log(e)UAI = 0.815, log(e)AER/log(e)UAI = 0.860, log(e)AER/log(e)UAI = 0.830, log(e)AER/log(e) = 0.722, respectively. In the present study, log(e)UAI was found to correlate well with log(e)AER. As AER is generally accepted to be the most reliable index to know the stage of albuminuria, UAI is considered to be clinically useful.</p>
Keywords albumin excretion rate urinary albumin index morning urine non-insulin dependent diabetes diabetic nephropathy
Amo Type Article
Published Date 1992-06
Publication Title Acta Medica Okayama
Volume volume46
Issue issue3
Publisher Okayama University Medical School
Start Page 165
End Page 168
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1502920
Web of Sience KeyUT A1992JB50400003
JaLCDOI 10.18926/AMO/31573
FullText URL fulltext.pdf
Author Okada, Soji| Miyai, Yooichiro| Masaki, Yoshitugu| Ichiki, Ken| Tanokuchi, So| Ishii, Keita| Hamada, Hiroshi| Ota, Zensuke|
Abstract <p>The aim of this study is to obtain data for improving a training program for patients with diabetes mellitus. One hundred eighty-seven patients with non-insulin dependent diabetes mellitus were tested with 20 questions about their knowledge for self-management of diabetes mellitus. Then to draw out factors in their personal backgrounds relating to their correct answers, multiple regression analyses were conducted. As a result, four factors showed significant differences in the following order: Educational careers &#62; ages &#62; duration of disease &#62; socioeconomic strata. The results of the present study have shown for the first time, that these four factors closely concern patients to acquire the necessary knowledge for their self-management of the disease. In addition, this study has raised some fundamental problems regarding the training program for patients: how education should be given to patients.</p>
Keywords knowledge neccessary for self-management of diabetes factors involved in the knowledge educational career age factors duration of diabetes socioeconomic strata
Amo Type Article
Published Date 1993-04
Publication Title Acta Medica Okayama
Volume volume47
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 94
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8506755
Web of Sience KeyUT A1993LA45200004
Author Morikawa, Yoshitaka| Hamada, Hiroshi|
Published Date 1980-11-29
Publication Title Memoirs of the School of Engineering, Okayama University
Volume volume15
Issue issue1
Content Type Departmental Bulletin Paper