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ID 31736
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Author
Gomita, Yutaka
Ichimaru, Yasuyuki
Ohizumi, Norihide
Yamada, Hirotoshi
Moriyama, Mimehiro
Araki, Yasunori
Abstract

The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the "sender" mice that received electric shocks on the feet and responded by squealing and jumping, and the "responder" mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in "responder" and "sender" mice, and by diazepam at a dose of 1 mg/kg, per os, in "responder" mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam.

Keywords
gastric ulcer
clotiazepam
non-physical and physical stimuli
mice
Amo Type
Article
Published Date
1987-12
Publication Title
Acta Medica Okayama
Volume
volume41
Issue
issue6
Publisher
Okayama University Medical School
Start Page
275
End Page
278
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT