JaLCDOI 10.18926/AMO/30688
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Hosokawa, Masao| Goda, Yoshinori| Akagi, Katsumi| Takeyama, Hiroyasu| Kimura, Ikuro|
Abstract <p>Numerical changes in peripheral blood monocytes were examined in 125 patients with bronchial asthma using a new direct method of counting blood monocytes. The number of monocytes in non-attack stages of bronchial asthma was similar to that of healthy controls. The monocyte count observed in overall cases showed a significantly higher value both in pre-attack and attack stages than in non-attack stages. Changes in the number of monocytes in an individual spontaneous asthmatic cycle tended to increase in pre-attack stages, increase more markedly during asthma attacks, then to decrease after the attack was alleviated. Monocytes in cases with a positive test for bronchial challenge to house dust extract changed in almost the same manner as for spontaneous asthma attacks. The number of monocytes did not change during bronchospasm provoked by inhalation of acetylcholine. Exercise-induced asthma patients exhibited indefinite changes of monocytes; that is, some cases showed a significant increase in the number of monocytes related to the asthma cycle, but other cases did not show any appreciable change. These findings suggest that the number of monocytes in the peripheral blood may change in close relation to asthma attacks elicited by allergic reactions.</p>
Keywords blood monocytes nonspecific esterase staining bronchial asthma
Amo Type Article
Published Date 1982-10
Publication Title Acta Medica Okayama
Volume volume36
Issue issue5
Publisher Okayama University Medical School
Start Page 341
End Page 348
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7180570
Web of Sience KeyUT A1982PN03500003
JaLCDOI 10.18926/AMO/30530
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Takahashi, Kiyoshi| Goda, Yoshinori| Sasaki, Yoshihede| Harada, Hiroshi| Kimura, Ikuro|
Abstract <p>Sixty-four patients with confirmed bronchial asthma were treated with HC 20-511 (Ketotifen). HC20-511 was evaluated to be very effective in 6.3%, effective in 50.0% and slightly effective in 10.9% of these patients. The appearance of reactive basophils was inhibited by HC 20-511 in 5 out of 6 cases of reaction to house dust, in all three cases with buckwheat allergy to their allergen and in 7 out of 11 cases to anti-IgE. These results confirm that HC 20-511 inhibits type I allergic reactions induced by specific allergen and IgE.</p>
Keywords bronchial asthma ketotifen basophil reactivity allergens anti-IgE
Amo Type Article
Published Date 1980-12
Publication Title Acta Medica Okayama
Volume volume34
Issue issue6
Publisher Okayama University Medical School
Start Page 383
End Page 388
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6451144
Web of Sience KeyUT A1980KZ17800004