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ID 48283
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Author
Ghosh, Souvik
Alam, Mohammed Mahbub
Ahmed, Muzahed Uddin
Talukdar, Rafiqul Islam
Paul, Shyamal Kumar
Kobayashi, Nobumichi
Abstract
This study reports the first complete genome sequence of a caprine group A rotavirus (GAR) strain, GO34. The VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes of strain GO34, detected in Bangladesh, were assigned to the G6-P[1]-I2-R2-C2-M2-A11-N2-T6-E2-H3 genotypes, respectively. Strain GO34 was closely related to the VP4, VP6–7 and NSP4–5 genes of bovine GARs and the NSP1 gene of GO34 to an ovine GAR. Strain GO34 shared low nucleotide sequence identities (<90 %) with VP2–3 genes of other GARs, and was equally related to NSP3 genes of human, ruminant and camelid strains. The VP1, VP6 and NSP2 genes of strain GO34 also exhibited a close genetic relatedness to human G2, G6, G8 and G12 DS-1-like GARs, whereas the NSP1 of GO34 was also closely related to human G6P[14] strains. All these findings point to a common evolutionary origin of GO34 and bovine, ovine, antelope, guanaco and human G6P[14] GARs, although phylogenetically GO34 is not particularly closely related to any other rotavirus strains known to date.
Published Date
2010-09
Publication Title
Journal of General Virology
Volume
volume91
Issue
issue9
Start Page
2367
End Page
2373
ISSN
0022-1317
NCID
AA00698722
Content Type
Journal Article
Project
Collaborative Research of Okayama University for Infectious Diseases in India
Official Url
http://vir.sgmjournals.org/content/91/9/2367
language
英語
Copyright Holders
© 2010 SGM
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Refereed
True
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