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ID 16040
Eprint ID
16040
FullText URL
Thumnail 99_1403.pdf 347 KB
Title Alternative
Anti-tumor activity and production of cytotoxic factor by Lymphokine-activated killer cells
Author
Gangi, Junichi
Abstract
Lymphokine-activated killer (LAK) cells can be generated by incubating peripheral blood lymphocytes in recombinant Interleukin―2. LAK cells kill fresh autologous and allogeneic human tumor cells in vitro. The adoptive transfer of these LAK cells into tumor-bearing hosts can mediate the cure of disseminated cancer in a variety of animal model systems. But the mechanism of target cell killing by LAK cells is as yet undefined. We have postulated that such killing may involve some soluble cytotoxic factors produced and secreted by LAK cells. LAK cells were induced by mitogens and tumor cells to secrete cytotoxic factors against L929 cells. LAK cells produced cytotoxic factors within 2 hr after induction and maximal production was observed 6 hr after induction. There was a good correlation between in vitro LAK cell activity and production of cytotoxic factors. We have identified one of these cytotoxic factors as tumor necrosis factor (TNF). LAK cells lost their in vitro cytotoxic activity and TNF producibility after treatment with OKT-8 antibody. These findings suggest that TNF may be a mediator of in vitro LAK cell activity.
Keywords
LAK細胞
細胞障害活性
細胞障害因子
腫瘍壊死因子
Published Date
1987-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1403
End Page
1410
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/11-12/99_11-12_1403/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma