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ID 52857
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Author
Wakamori, Takaaki
Shinko, Aiko
Sasada, Susumu
Sasaki, Tatsuya
Furuta, Tomohisa
Abstract
Objective: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4 +/- 2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4 +/- 17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.
Keywords
Parkinson's disease
Cognitive functions
Disease severity
Hallucinations
SPECT
Published Date
2014-04
Publication Title
Parkinsonism and Related Disorders
Volume
volume20
Issue
issue4
Start Page
415
End Page
420
ISSN
1353-8020
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52827
language
英語
Copyright Holders
(C) 2014 Elsevier Ltd. All rights reserved.
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Refereed
True
DOI
Web of Sience KeyUT