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ID 52790
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Author
Wada, Nozomu
Yasunaka, Tetsuya
Nishina, Sohji
Korenaga, Masaaki
Hino, Keisuke
Fujioka, Shin-ichi
Osawa, Toshiya
Itoshima, Tatsuya
Kawanaka, Miwa
Yamada, Gotaro
Kariyama, Kazuya
Takayama, Hiroki
Kubota, Junichi
Morimoto, Yoichi
Mizushima, Takaaki
Yamashita, Haruhiko
Tanioka, Hiroaki
Negoro, Yuji
Toshimori, Junichi
Kobashi, Haruhiko
Hirano, Atsushi
Itano, Yasuo
Abstract
Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.
Keywords
acute hepatitis
hepatitis B virus
Amo Type
Original Article
Published Date
2014-08
Publication Title
Acta Medica Okayama
Volume
volume68
Issue
issue4
Publisher
Okayama University Medical School
Start Page
243
End Page
247
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2014 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT