ID | 31028 |
JaLCDOI | |
FullText URL | |
Author |
Wakiguchi, Hiroshi
Fujieda, Mikiya
Matsumoto, Kenji
Ohara, Yuji
Wakiguchi, Akiko
Kurashige, Takanobu
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Abstract | Natural killer (NK) cell activity, lymphokine activated killer (LAK) activity and Epstein-Barr virus specific cytotoxic T lymphocyte (EBV-CTL) activity were examined in 10 children with chronic active EB-virus infection and an adult with persistently positive early antigen-antibody to EB-virus. NK cell activity against erythroleukemia cell line K-562 was significantly (p less than 0.005) lower in the patients (22.3 +/- 8.5%, mean +/- SD) than in normal controls (40.4 +/- 15.9%). Spontaneous cytotoxicity against an EB-virus transformed autologous lymphoblastoid cell line was 15.0 +/- 7.6% in the patients, and was comparable to spontaneous cytotoxicity activity in normal controls (11.7 +/- 4.3%). LAK activity against Raji cells was significantly (p less than 0.02) lower in the patients (14.6 +/- 11.4%) than in normal controls (29.2 +/- 15.9%). EBV-CTL activity against an EB-virus transformed autologous lymphoblastoid cell line was significantly (p less than 0.005) lower in the patients (11.8 +/- 5.5%) than in seropositive normal controls (33.7 +/- 14.7%). No regression of the lymphoblastoid cell line was observed when EBV-CTL activity of the patients was tested by regression assay. It is conceivable that defects in both EB-virus specific and nonspecific killer cell activities play important roles in the pathogenetic abnormalities which allow EB-virus infection to progress to a chronic active state. |
Keywords | chronic active EB-virus infection
EB-virus specific cytotoxic T lymphocyte
natural killer
lymphokine activated killer
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Amo Type | Article
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Published Date | 1988-06
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Publication Title |
Acta Medica Okayama
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Volume | volume42
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Issue | issue3
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Publisher | Okayama University Medical School
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Start Page | 137
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End Page | 142
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
英語
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Sience KeyUT |