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ID 51011
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Author
Esumi, Satoru
Sagara, Hidenori
Nakamoto, Akihiko
Gomita, Yutaka
Abstract
Rationale: It was recently demonstrated that the priming stimulation effect (PSE) in the runway model of intracranial self-stimulation (ICSS) can be used as a model system to study the motivational effects of drugs. However, the characteristics of this navel experimental model have not been fully clarified. Objective: To elucidate the involvement of dopamine uptake inhibition in motivated behavior and the difference in experimental characteristics between closely related experimental models, we investigated the effects of the dopamine uptake inhibitor GBR12909 in the runway ICSS model, in the forced swimming test (FST), and on conditioned place preference (CPP). In addition, the role of dopamine receptor signaling in the runway model was evaluated using dopamine receptor agonists and antagonists. Results: GBR12909 dose-dependently increased running speed on the runway and decreased immobility time in the FST without affecting the time spent in the drug-associated compartment in CPP tests. The effect of GBR12909 in the runway model was inhibited by pre-treatment with the dopamine receptor antagonists haloperidol and raclopride. The dopamine receptor agonists SKF38393 and quinpirole dose-dependently decreased running speed. Conclusions: These results demonstrate that GBR12909 displays motivation-enhancing and antidepressant-like effects without place conditioning effects. In addition, the mechanisms of PSE enhancement in the runway ICSS model are different from those underlying closely associated experimental models and are mediated by increases in dopamine signaling.
Keywords
Motivation
Intracranial Self-stimulation
Forced swimming test
Conditioned place preference
GBR12909
Quinpirole
Published Date
2013-04-15
Publication Title
Behavioural Brain Research
Volume
volume243
Start Page
313
End Page
321
ISSN
0166-4328
Content Type
Journal Article
Official Url
http://www.sciencedirect.com/science/article/pii/S0166432812007012
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/50696
language
英語
Copyright Holders
(C) 2012 Elsevier B.V. All rights reserved.
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Refereed
True
DOI
Web of Sience KeyUT