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ID 48840
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Author
Yamato, Keiko
Nishiyama, Yuichi
Morii, Yuji
Etani, Reo
Takata, Yuji
Sakoda, Akihiro
Ishimori, Yuu
Abstract
Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone’s attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300–500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
Keywords
radon
carbon tetrachloride
oxidative damage
α-tocopherol
kidney
Published Date
2012-10
Publication Title
Renal Failure
Volume
volume34
Issue
issue9
Publisher
Informa Healthcare
Start Page
1181
End Page
1187
ISSN
1525-6049
NCID
AA12520251
Content Type
Journal Article
Official Url
http://informahealthcare.com/doi/abs/10.3109/0886022X.2012.717496
language
英語
File Version
author
Refereed
True
DOI
PubMed ID