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ID 32277
JaLCDOI
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Author
Karakas, Zeynep
Agaoglu, Leyla
Biner, Betul
Devecioglu, Omer
Anak, Sema
Yalman, Nevin
Unuvar, Aysegul
Celik, Alaattin
Gedikoglu, Gunduz
Abstract

Fifty-one children (median age: 4.5 years; 4 months-16 years) diagnosed with rhabdomyosarcoma were treated in our center between 1980-1999. The primary sites were head and neck in 31.4%, the genito-urinary system in 21.6%, and extremities in 9.8% of the patients. The histopathologic subtypes were embryonal in 80.4%, alveolar in 9.8%, and undifferentiated in 9.8%. The majority of the patients were considered group III (47%) and group IV (25.5%) according the criteria of the Intergroup Rhabdomyosarcoma Study (IRS). Primary total tumour resection was performed in only 27.5% of the patients. The patients were treated with assigned regimens of IRS II and IRS III protocols. Radiotherapy was applied to 92.1% of the patients. Thirty-four patients (66.7%) were lost to follow up, and of the remaining 17 patients, 7 patients (41.2%) died, relapse occurred in 9 patients (52.9%) and 10 patients (58.8%) are alive. The percentage of cases lost to follow up during the first 10 years and the following 9 years of the study were 77.4% and 50%, respectively. In compliance with cancer treatment remains a major problem in developing countries.

Keywords
rhabdomyosarcoma
pediatric onocology
chemotherapy
Amo Type
Article
Published Date
2000-08
Publication Title
Acta Medica Okayama
Volume
volume54
Issue
issue4
Publisher
Okayama University Medical School
Start Page
173
End Page
177
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT