FullText URL CGI_17_11_1843.pdf fig.pdf
Author Ohta, Yasuyuki| Darwish, Mohamed| Hishikawa, Nozomi| Yamashita, Toru| Sato, Kota| Takemoto, Mami| Abe, Koji|
Abstract AIM: To evaluate the therapeutic effects of switching from one acetylcholinesterase inhibitor (ChEI), donepezil, galantamine or rivastigmine, to another in Alzheimer's disease patients. METHODS: We retrospectively enrolled 171 Alzheimer's disease patients, whose ChEI medication was changed. The patients were evaluated on three major aspects of dementia - cognitive, affective and activities of daily living (ADL) measures - at 6 months (M) before the drug switch, at the time of drug switch (baseline), and at 3 M and 6 M after the drug switch. RESULTS: The doses of the three ChEI were significantly lower at 6 M after the switch compared with the pre-switch doses. Improvements in apathy were found at 3 M when switching from donepezil to galantamine, but not to rivastigmine, but this switch had adverse effects on ADL. Improvements in cognitive scores at 3 M were also found when switching from galantamine to rivastigmine, but not to donepezil. However, both of these changes improved Abe's Behavioral and Psychological Symptoms of Dementia scores (ABS), except ADL. Switching from rivastigmine to donepezil worsened ABS at 6 M, but preserved cognitive and ADL scores. CONCLUSIONS: The present study suggests that despite a relatively lower dose of ChEI after the switch, switching from donepezil or rivastigmine preserved cognitive functions for at least 6 M. Switching from galantamine to rivastigmine improved Mini-Mental State Examination and ABS at 3 M, but did not improve ADL scores. Geriatr Gerontol Int 2017; 17: 1843-1848.
Keywords Alzheimer's disease donepezil drug switch galantamine rivastigmine
Note This is an Accepted Manuscript of an article published by Wiley
Published Date 2017-11
Publication Title Geriatrics & Gerontology International
Volume volume17
Issue issue11
Publisher Japan Geriatrics Society
Start Page 1843
End Page 1848
ISSN 1444-1586
NCID AA1155729X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28060449
DOI 10.1111/ggi.12971
Web of Sience KeyUT 000416330000009
Related Url isVersionOf https://doi.org/10.1111/ggi.12971