JaLCDOI 10.18926/AMO/31509
FullText URL fulltext.pdf
Author Hamaya, Kazuo| Doi, Kenji| Tanaka, Toshio| Nishimoto, Akira|
Abstract <p>Glial fibrillary acidic protein (GFAP) was purified from human spinal cord and cerebral white matter. GFAP was localized by an immuno-peroxidase method in normal adult and fetal human brains, rat brains, and 152 central nervous system (CNS) tumors. GFAP was found in reactive and normal astrocytes, immature cells of fetal brain at the 18th to 21st gestational weeks, and normal rat astrocytes. This GFAP staining was quite specific for glial tumors, including astrocytomas, glioblastomas, astroblastomas, and ependymomas. GFAP-positive cells were also found in oligodendrogliomas and choroid plexus papillomas, and they were interpreted as being astroglial or ependymal differentiations. Stromal cells in cerebellar hemangioblastomas were negative. However, engulfed astrocytes were found at the periphery of such tumors and often adjacent to the proliferate blood vessels. In meningiomas, neurinomas, metastatic carcinomas, pituitary adenomas and other non-glial tumors, GFAP-positive cells were not identified.</p>
Keywords glial librillary acidic protein central nervous system tumors
Amo Type Article
Published Date 1985-12
Publication Title Acta Medica Okayama
Volume volume39
Issue issue6
Publisher Okayama University Medical School
Start Page 453
End Page 462
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4091041
Web of Science KeyUT A1985AWT4000005