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ID 55453
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Huang, Xin-Yuan Institute of Biological and Environmental Sciences, University of Aberdeen
Deng, Fenglin Institute of Plant Science and Resources, Okayama University
Yamaji, Naoki Institute of Plant Science and Resources, Okayama University
Pinson, Shannon R.M. USDA-ARS Dale Bumpers National Rice Research Center
Fujii-Kashino, Miho Institute of Plant Science and Resources, Okayama University
Danku, John Institute of Biological and Environmental Sciences, University of Aberdeen
Douglas, Alex
Guerinot, Mary Lou Department of Biological Sciences, Dartmouth College
Salt, David E. Institute of Biological and Environmental Sciences, University of Aberdeen
Ma, Jian Feng Institute of Plant Science and Resources, Okayama University
Abstract
Rice is a major source of calories and mineral nutrients for over half the world's human population. However, little is known in rice about the genetic basis of variation in accumulation of copper (Cu), an essential but potentially toxic nutrient. Here we identify OsHMA4 as the likely causal gene of a quantitative trait locus controlling Cu accumulation in rice grain. We provide evidence that OsHMA4 functions to sequester Cu into root vacuoles, limiting Cu accumulation in the grain. The difference in grain Cu accumulation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 transport activity. The allele associated with low grain Cu was found in 67 of the 1,367 rice accessions investigated. Identification of natural allelic variation in OsHMA4 may facilitate the development of rice varieties with grain Cu concentrations tuned to both the concentration of Cu in the soil and dietary needs.
Keywords
Genetic variation
Natural variation in plants
Quantitative trait
Rice
Note
This is an article published by Nature Publishing Group
Published Date
2016-07
Publication Title
Nature Communications
Volume
volume7
Publisher
Nature Publishing Group
Start Page
12138
ISSN
2041-1723
NCID
AA12645905
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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Related Url
https://doi.org/10.1038/ncomms12138