FullText URL NatCommun_12138.pdf
Author Huang, Xin-Yuan| Deng, Fenglin| Yamaji, Naoki| Pinson, Shannon R.M.| Fujii-Kashino, Miho| Danku, John| Douglas, Alex| Guerinot, Mary Lou| Salt, David E.| Ma, Jian Feng|
Abstract Rice is a major source of calories and mineral nutrients for over half the world's human population. However, little is known in rice about the genetic basis of variation in accumulation of copper (Cu), an essential but potentially toxic nutrient. Here we identify OsHMA4 as the likely causal gene of a quantitative trait locus controlling Cu accumulation in rice grain. We provide evidence that OsHMA4 functions to sequester Cu into root vacuoles, limiting Cu accumulation in the grain. The difference in grain Cu accumulation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 transport activity. The allele associated with low grain Cu was found in 67 of the 1,367 rice accessions investigated. Identification of natural allelic variation in OsHMA4 may facilitate the development of rice varieties with grain Cu concentrations tuned to both the concentration of Cu in the soil and dietary needs.
Keywords Genetic variation Natural variation in plants Quantitative trait Rice
Note This is an article published by Nature Publishing Group
Published Date 2016-07
Publication Title Nature Communications
Volume volume7
Publisher Nature Publishing Group
Start Page 12138
ISSN 2041-1723
NCID AA12645905
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 27387148
DOI 10.1038/ncomms12138
Web of Sience KeyUT 000380305000001
Related Url https://doi.org/10.1038/ncomms12138