JaLCDOI 10.18926/AMO/30398
FullText URL fulltext.pdf
Author Moriyama, Masahiro| Domoto, Haruyo| Yamashita, Syoichi| Furuno, Katsushi| Oishi, Ryozo| Kawasaki, Hiromu| Gomita, Yutaka|
Abstract <p>We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.</p>
Keywords phenobarbital pharmacokinetics pregnancy plasma concentrations
Amo Type Article
Published Date 1995-10
Publication Title Acta Medica Okayama
Volume volume49
Issue issue5
Publisher Okayama University Medical School
Start Page 237
End Page 240
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8585393
Web of Science KeyUT A1995TC51800002