FullText URL fulltext.pdf
Author Kin, Kyohei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao|
Keywords animal model alpha-synuclein DJ-1 neurotoxin Parkin Parkinson's disease pesticide PINK1 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine
Published Date 2019-10-30
Publication Title International Journal of Molecular Sciences
Volume volume20
Issue issue21
Publisher MDPI
Start Page E5402
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31671557
DOI 10.3390/ijms20215402
Web of Science KeyUT 000498946100160
Related Url isVersionOf https://doi.org/10.3390/ijms20215402
Author Hishikawa, Tomohito| Sugiu, Kenji| Murai, Satoshi| Takahashi, Yu| Kidani, Naoya| Nishihiro, Shingo| Hiramatsu, Masafumi| Date, Isao| Satow, Tetsu| Iihara, Koji| Sakai, Nobuyuki| JR-NET2 and JR-NET3 study groups.|
Keywords Complication Embolization Intracranial tumor Risk factors
Note This fulltext will be available in Aug 2020|
Published Date 2019-06-07
Publication Title Acta Neurochirurgica
Volume volume161
Issue issue8
Publisher Springer Nature
Start Page 1675
End Page 1682
ISSN 00016268
NCID AA0050885X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31172282
DOI 10.1007/s00701-019-03970-w
Web of Science KeyUT 000475688800023
Related Url isVersionOf https://doi.org/10.1007/s00701-019-03970-w
JaLCDOI 10.18926/AMO/55302
FullText URL 71_4_263.pdf
Author Toyoshima, Atsuhiko| Yasuhara, Takao| Date, Isao|
Abstract  To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application.
Keywords mesenchymal stem cell ischemic stroke cell transplantation clinical trial
Amo Type Review
Published Date 2017-08
Publication Title Acta Medica Okayama
Volume volume71
Issue issue4
Publisher Okayama University Medical School
Start Page 263
End Page 268
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28824181
FullText URL Acta_Neurochir_159_7_1329.pdf
Author Kidani, Naoya| Sugiu, Kenji| Hishikawa, Tomohito| Hiramatsu, Masafumi| Haruma, Jun| Nishihiro, Shingo| Takahashi, Yu| Date, Isao|
Keywords De novo aneurysm Hemodynamic stress Stent-assisted coil embolization Vertebral artery dissecting aneurysm
Published Date 2017-07
Publication Title Acta Neurochirurgica
Volume volume159
Issue issue7
Publisher Springer
Start Page 1329
End Page 1333
ISSN 00016268
NCID AA0050885X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28493024
Web of Science KeyUT 000403508400024
Related Url https://doi.org/10.1007/s00701-017-3204-2
JaLCDOI 10.18926/AMO/55201
FullText URL 71_3_191.pdf
Author Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
Abstract  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
Keywords fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 200
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655938
JaLCDOI 10.18926/AMO/54987
FullText URL 71_2_179.pdf
Author Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao|
Abstract Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management.
Keywords cerebral perfusion encephalopathy child intracranial pressure neurological intensive care
Amo Type Short Communication
Published Date 2017-04
Publication Title Acta Medica Okayama
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 179
End Page 180
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420900
JaLCDOI 10.18926/AMO/54813
FullText URL 70_6_493.pdf
Author Yasuhara, Takao| Kuwahara, Ken| Sasada, Susumu| Toyoshima, Atsuhiko| Morimoto, Jun| Kin, Kyohei| Manabe, Hiroaki| Miyoshi, Yasuyuki| Kusumegi, Akira| Takahashi, Yuichiro| Ito, Kiyoshi| Date, Isao|
Abstract Unexpected injuries can have a profound effect on a surgeonʼs performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a ʻSurgical Body Supportʼ device. Similarly injured surgeons may benefit from such support.
Keywords Achilles tendon rupture electromyogram genuflection injured leg standing position
Amo Type Short Communication
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 493
End Page 496
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003675
JaLCDOI 10.18926/AMO/54497
FullText URL 70_4_229.pdf
Author Hishikawa, Tomohito| Sugiu, Kenji| Date, Isao|
Abstract About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.
Keywords clinical research moyamoya disease
Amo Type Review
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 229
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549666
Web of Science KeyUT 000384748600001
Title Alternative Hosting the 18th JASMEE Academic Meeting in Okayama
FullText URL 128_69.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 69
End Page 70
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.69
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.69
NAID 120005752921
Title Alternative Hosting the 16th Annual Meeting of the Japanese Society for Normal Pressure Hydrocephalus
FullText URL 127_259.pdf
Author Date, Isao|
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 259
End Page 260
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.259
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.259
NAID 130005116806
Author Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao|
Published Date 2013-04-15
Publication Title SpringerPlus
Volume volume2
Content Type Journal Article
Author Ishida, Joji| Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Fujii, Kentaro| Shimazu, Yosuke| Oka, Tetsuo| Date, Isao|
Published Date 2014-04
Publication Title Translational Oncology
Volume volume7
Issue issue2
Content Type Journal Article
Author Wakamori, Takaaki| Agari, Takashi| Yasuhara, Takao| Kameda, Masahiro| Kondo, Akihiko| Shinko, Aiko| Sasada, Susumu| Sasaki, Tatsuya| Furuta, Tomohisa| Date, Isao|
Published Date 2014-04
Publication Title Parkinsonism and Related Disorders
Volume volume20
Issue issue4
Content Type Journal Article
Author Fujii, K| Kurozumi, K| Ichikawa, T| Onishi, M| Shimazu, Y| Ishida, J| Chiocca, EA| Kaur, B| Date, I|
Published Date 2013-08
Publication Title Cancer Gene Therapy
Volume volume20
Issue issue8
Content Type Journal Article
Author Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao|
Published Date 2013-09
Publication Title Neuroradiology
Volume volume55
Issue issue9
Content Type Journal Article
Author Tayra, Judith Thomas| Kameda, Masahiro| Yasuhara, Takao| Agari, Takashi| Kadota, Tomohito| Wang, Feifei| Kikuchi, Yoichiro| Liang, Hanbai| Shinko, Aiko| Wakamori, Takaaki| Vcelar, Brigitta| Weik, Robert| Date, Isao|
Published Date 2013-03-28
Publication Title Brain Research
Volume volume1502
Content Type Journal Article
Author Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Article
Author Okuma, Yu| Liu, Keyue| Wake, Hidenori| Haruma, Jun| Yoshino, Tadashi| Ohtsuka, Aiji| Takahashi, Hideo| Mori, Shuji| Nishibori, Masahiro| Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Onishi, Manabu| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Fujii, Kentaro| Yoshida, Koichi| Inoue, Satoshi| Michiue, Hiroyuki| Chiocca, E. Antonio| Kaur, Balveen| Date, Isao|
Published Date 2013-04
Publication Title Neuropathology
Volume volume33
Issue issue2
Content Type Journal Article
Author Maruo, Tomoko| Ichikawa, Tomotsugu| Kanzaki, Hirotaka| Inoue, Satoshi| Kurozumi, Kazuhiko| Onishi, Manabu| Yoshida, Koichi| Kambara, Hirokazu| Ouchida, Mamoru| Shimizu, Kenji| Tamaru, Seiji| Chiocca, E. Antonio| Date, Isao|
Published Date 2013-06
Publication Title Neuropathology
Volume volume33
Issue issue3
Content Type Journal Article