JaLCDOI 10.18926/AMO/31967
FullText URL fulltext.pdf
Author Kurtoglu, Zeliha| Ozturk, Ahmet Hakan| Bagdatoglu, Celal| Polat, Gurbuz| Aktekin, Mustafa| Uzmansel, Deniz| Camdeviren, Handan| Bagdatoglu, Ozlen| Sargon, Mustafa|
Abstract <p>In this study, we evaluated the effects of trapidil on crush injury by monitoring nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels and by transmission electron microscopy in the rat sciatic nerve. The sciatic nerve was compressed for 20 sec by using a jewelers forceps. Trapidil treatment groups were administrated a single dose of trapidil (8 mg/kg) intraperitoneally just after the injury. The crush and crush + trapidil treatment groups were evaluated on the 2nd, 7th, 15th, 30th and 45th days of the post-crush period. On the 7th and 15th days, damage in thin and thick myelinated axons, endoneural edema and mitochondrial swelling were less severe in the trapidil group histopathologically. These findings supported the idea that trapidil prevented cell damage and edema at the injury site. Day/group interaction with regard to serum nitric oxide, malondialdehyde and transforming growth factor-Beta2 levels did not show significant changes.</p>
Keywords trapidil crush injury peripheral nerve electron microscopy nitric oxide
Amo Type Article
Published Date 2005-04
Publication Title Acta Medica Okayama
Volume volume59
Issue issue2
Publisher Okayama University Medical School
Start Page 37
End Page 44
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16049553
Web of Sience KeyUT 000228590000001