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ID 16031
Eprint ID
16031
FullText URL
Thumnail 100_939.pdf 2.59 MB
Title Alternative
Studies on the role of the kallikrein-kinin system in bronchial asthma Part 2. Determination of kallikrein-like activity in bronchoalveolar lavage fluid
Author
Takai, Yutaka
Abstract
Kallikrein-like activity was evaluated in the bronchoalveolar lavage fluid (BALF) of 43 patients (33 bronchial asthma patients and 10 controls) to study the inflammatory response in the lower respiratory tract of asthma patients. The appearance rate of BALF kallikrein-like activity (BKLA) was 25.0% in asthmatics, and 60.0% in asthmatics after provocation by a specific antigen, whereas it was negative in healthy subjects. The increase in BKLA in asthmatic subjects was significant. BKLA in patients with an immediate asthmatic response after provocation turned negative, whereas it was positive in their ordinary BALF. On the contrary, BKLA after provocation in those with a late asthmatic response turned positive, whereas it was negative in their ordinary BALF.Characterization using three protease inhibitors indicated that BKLA had an enzymatic character similar to plasma kallikrein. These results suggest that the activation of the kallikrein-kinin system may have a possible role during anaphylaxis in asthmatics.
Keywords
bronchial asthma
bronchoalveolar lavage fluid
kallikrein-like activity
neutrophils chemotaxis
immediate and late asthmatic response
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
939
End Page
950
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/9-10/100_9-10_939/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma