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ID 16028
Eprint ID
16028
FullText URL
Thumnail 100_927.pdf 699 KB
Title Alternative
Studies on the role of the kallikrein-kinin system in bronchial asthma Part 1. Relationship between bronchial asthma and Hageman factor dependent pathways
Author
Takai, Yutaka
Abstract
The relationship between bronchial asthma and Hageman factor dependent pathways (the contact phase of the internal coagulation system) was studied in reference to the possible role of the kallikrein-kinin system in asthmatics.The plasma Hageman factor level was significantly lower in asthmatics (74.8±27.7% in remission, and 75.4±26.3% during in attack) than in healthy subjects (98.1±27.6%), and the plasma prekallikrein value was also lower in asthmatics (88.8±25.3% in remission, and 75.1±23.8% during in attack) than in normal controls (105.7±19.7%). Especially, the plasma prekallikrein level was significantly lower in asthmatics during in attack than in those in remission. The plasma bradykinin level of asthmatics in remission tended to be higher (98.8±89.8pg/ml) than that of healthy subjects (47.1±29.6pg/ml). The plasma high molecular weight kininogen level was not significantly different between asthmatics and normal subjects. These results suggest that the plasma kallikrein-kinin system may play a role in the pathophysiology of bronchial asthma.
Keywords
bronchial asthma
Hageman factor dependent pathways
kallikrein-kinin system
atopic asthma
intractable asthma
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
927
End Page
937
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/9-10/100_9-10_927/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma