このエントリーをはてなブックマークに追加
ID 817
Eprint ID
817
FullText URL
Title Alternative
グラヤノトキシンD環の化学修飾
Author
Iwasa, Junkichi
Kawanishi, Tetsuroh
Handa, Satoshi
Kamano, Hideki
Yamamoto, Shingo
Okamoto, Manabu
Takeda, Norimasa
Nakamura, Mikihiko
Masutani, Tetsuya
Shiro, Motoo
Baba, Naomichi
Seyama, Issei
Abstract
Grayanotoxin (GTX), one of the lipid-soluble Na+ channel openers, contains four rings (A, B, C and D) and the chemical groups essential for the pharmacological action are located on the A- and B-rings. To study the biological significance of functional groups on the D-ring, 51 new derivatives were prepared from α-dihydro GTX- 11 . These new compounds and the previously prepared GTXS ere directly applied to the intracellular phase of internally perfused squid giant axons.
Published Date
1992
Publication Title
岡山大学農学部学術報告
Publication Title Alternative
Scientific Reports of the Faculty of Agriculture Okayama University
Volume
volume79
Issue
issue1
Publisher
岡山大学農学部
Publisher Alternative
Faculty of Agriculture, Okayama University
Start Page
1
End Page
35
ISSN
0474-0254
NCID
AN00033029
Content Type
Departmental Bulletin Paper
language
英語
File Version
publisher
Refereed
False
Eprints Journal Name
srfa