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Title Alternative
Radiosensitization by telomerase-dependent oncolytic adenovirus
Author
Kuroda, Shinji
Fujiwara, Toshiya
Yamasaki, Yasumoto
Yano, Syuya
Hashimoto, Yuuri
Watanabe, Yuichi
Noma, Kazuhiro
Urata, Yasuo
Abstract
DNA修復機能阻害は放射線感受性を増強させるため,DNA修復に関与する因子の阻害剤は放射線増感剤となり得る.我々の開発したテロメラーゼ依存的腫瘍融解アデノウイルス製剤OBP-301(テロメライシン)は,アデノウイルスE1B55kDaタンパクを介して細胞のDNA修復に重要な役割を果たすMRN複合体(Mre11,Rad50,NBS1)を分解する機能を有する.このMRN複合体の分解によりATM(ataxia-telangiectasia mutated)の活性化が抑制され結果的にDNA修復機構が阻害される.我々はOBP-301と放射線との併用が強力な相乗効果を生み出すことをマウスの皮下腫瘍モデルおよび食道癌同所性モデルにおいて証明した.これらの結果はOBP-301が将来有望な放射線増感剤となり得ることだけでなく,E1B55kDaタンパクを産生する腫瘍融解アデノウイルス製剤と放射線との併用が悪性腫瘍に対する有力な治療戦略となり得ることを示す.
Keywords
アデノウイルス
E1B55kDa
MRN複合体
DNA修復
放射線感受性
Note
平成22年度岡山医学会賞(林原賞) (The 2010 Okayama Medical Association Award)
Published Date
2011-08-01
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume123
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
103
End Page
109
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
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日本語
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Copyright (c) 2011 岡山医学会
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