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ID 12845
Eprint ID
12845
FullText URL
Title Alternative
Mutational and epigenetic evidence for independent pathways for lung adenocarcinoma
Author
Date, Hiroshi
Keywords
肺腺癌
EGFR
Kras
methylation
Note
平成18年度岡山医学会賞(山田賞)受賞論文
Published Date
2008-05-01
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume120
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
7
End Page
11
ISSN
00301558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
References
1) Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C,
Thun, MJ:Cancer statistics, 2006. CA:Cancer J Clin (2006) 56,106-130.
2) Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S,
Okimoto RA, Brannigan BW, Harris PL, Haserlat SM,
Supko JG, Haluska FG, Louis DN, Christiani DC, et al.:
Activating mutations in the epidermal growth factor
receptor underlying responsiveness of non-small-cell lung
cancer to gefitinib。 N Engl J Med (2004) 350,2129-2139.
3) Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel
S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K,
Sasaki H, et al.:EGFR mutations in lung cancer:
correlation with clinical response to gefitinib therapy.
Science (2004) 304,1497-1500.
4) Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M,
Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N,
Fujisawa T, Feng Z, et al.:Clinical and biological features
associated with epidermal growth factor receptor gene
mutations in lung cancers. J Natl Cancer Inst (2005) 97,
339-346.
5) Toyooka S, Tsuda T, Gazdar AF:The TP53 gene, tobacco
exposure, and lung cancer. Hum Mutat (2003) 21,229-239.
6) Toyooka S, Toyooka KO, Maruyama R, Virmani AK,
Girard L, Miyajima K, Harada K, Ariyoshi Y, Takahashi T, Sugio K, Brambilla E, Gilcrease M, et al.:DNA methylation profiles of lung tumors。 Mol Cancer Ther (2001) 1,61-67.
7) Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng
Z, Fukuyama Y, Virmani AK, Zochbauer-Muller S, Tsukuda K, Sugio K, Shimizu N, Shimizu K, et al.:Smoke exposure, histologic type and geography-related differencesin the methylation profiles of non-small cell lung cancer. Int
J Cancer (2003) 103,153-160.
8) Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M,
Hoda S, McIntosh J, Kurie J, Dmitrovsky E:Differential
expression of the epidermal growth factor receptor and its
ligands in primary non-small cell lung cancers and adjacent
benign lung。 Cancer Res (1993) 53,S2379-2385.
9) Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE:Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to downregulation of the receptors. Genes Dev (2006) 20,1496-1510.
10) Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S, Hatooka S, Shinoda M, Takahashi T, Yatabe Y:Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol (2005) 23,2513-2520.
11) Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T,
Mitsudomi T:Mutations of the epidermal growth factor
receptor gene in lung cancer:biological and clinical implications. Cancer Res (2004) 64,8919-8923.
12) Tokumo M, Toyooka S, Kiura K, Shigematsu H, Tomii K,
Aoe M, Ichimura K, Tsuda T, Yano M, Tsukuda K, Tabata
M, Ueoka H, et al.:The relationship between epidermal
growth factor receptor mutations and clinicopathologic
features in non-small cell lung cancers. Clin Cancer Res
(2005) 11,1167-1173.
13) Shigematsu H, Gazdar AF:Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer (2006) 118,257-262.
14) Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP:
Alterations in DNA methylation:a fundamental aspect of
neoplasia. Adv Cancer Res (1998) 72,141-196.
15) Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van
Engeland M, Weijenberg MP, Herman JG, Baylin, SB:A
genomic screen for genes upregulated by demethylation
and histone deacetylase inhibition in human colorectal
cancer. Nature genetics (2002) 31,141-149.
16) Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin
SB:Methylation-specific PCR:a novel PCR assay for
methylation status of CpG islands. Proc Natl Acad Sci USA
(1996) 93,9821-9826.
17) Serrano M, Lin AW, McCurrach ME, Beach D, Lowe
SW:Oncogenic ras provokes premature cell senescence
associated with accumulation of p53 and p16INK4a. Cell
(1997) 88,593-602.
18) Weinstein IB:Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science (2002) 297,63-64.
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
DOI
Eprints Journal Name
joma