Sort Key 7
Title Alternative Giant rectal gastrointestinal stromal tumor successfully resected by abdominoperineal resection combined with posterior vaginal wall resection
FullText URL 126_217.pdf
Author Iwakawa, Kazuhide| Nishie, Manabu| Tokunaga, Naoyuki| Miyaso, Hideaki| Iwagaki, Hiromi|
Abstract We report a case of giant rectal gastrointestinal stromal tumor (GIST) successfully resected by abdominoperineal resection combined with posterior vaginal wall resection. Our patient was a 79-year-old woman had been diagnosed as having von Recklinghausen disease at the age of 30 years. In 2006, a computed tomography (CT) scan revealed a tumor originating from the posterior wall of the rectum. In June 2010, she was admitted to our hospital with the chief complaint of bloody stool. A CT scan revealed a giant tumor that had increased to 9cm in size. Colonoscopy demonstrated a submucosal tumor, which was subsequently diagnosed by biopsy as a GIST. Due to the patient's continuous bleeding and abdominal pain, an emergent abdominoperineal resection was performed at that time. The tumor, which measured 8×9cm, was immunohistochemically positive for c-kit and CD34. Concomitant resection of the posterior wall of the vagina via the perineal approach provided a wide area to expose the tumor for a safe operation. The patient has been well with no sign of recurrence since the operation. This procedure is recommended as a useful approach for giant rectal GISTs or rectal cancer with invasion of the posterior pelvic wall.
Keywords 巨大直腸GIST(giant rectal GIST) 腹会陰式直腸切断術(abdominoperineal resection)
Note 症例報告 (Case Reports)
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Publisher 岡山医学会
Publisher Alternative Okayama Medical Association
Start Page 217
End Page 221
ISSN 0030-1558
NCID AN00032489
Content Type Journal Article
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
Refereed True
DOI 10.4044/joma.126.217
NAID 130004903245
Eprints Journal Name joma
References 1) Miettinen M, Lasota J : Gastrointestinal stromal tumors (GISTs) : definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol (2003) 54, 3-24. 2) 小西 毅, 渡邉聡明, 名川弘一 : 直腸gastrointestinal stromal tumor (GIST)の臨床的特徴. 日外科系連会誌 (2004) 29, 169-173. 3) Hirota S, Isozaki K, Moriyama Y, Hashimoto K : Gain of function mutations of c-kit in human gastrointestinal stromal tumors. Science (1998) 279, 577-580. 4) Maertens O, Prenen H, Rychter MD, Wozniak A, Sciot R, Pauwels P, Wever I, Vermeesch JR, Raedt T, Paepe A, Speleman F, Oosterom A, et al. : Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients. Hum Mol Genet (2006) 15, 1015-1023. 5) 王 孔志, 中井紀博, 岡田敏弘, 飯室勇二, 廣田誠一, 藤本治朗 : メシル酸イマチニブによる術前補助療法が奏効した巨大直腸GISTの1例. 日臨外会誌(2010)71, 1806-1811. 6) 山下和城, 久保添忠彦, 山村真弘, 松本英男, 浦上 淳, 平井敏弘, 角田 司 : Imatinib mesylateによるneoadjuvant therapyが有効であった巨大直腸GISTの1例. 日本大腸肛門病会誌(2006)59, 24-30. 7) Kusumoto Y, Soda K, Shuto Y, Konishi F : A case of gastrointestinal stromal tumor of the rectum resected by the transvaginal approach. Jichi Medical School Journal (2004) 27, 145-154. 8) 尾形 徹, 川本 純, 山東敬弘, 藤本三喜夫, 中井志郎, 増田哲彦, 安井 弥 : 直腸膣中隔に発症したgastrointestinal stromal tumor (uncommitted type) の1例. 日臨外会誌(2001)62, 988-991.
Author Otsuka, Shinya| Inagaki, Masaru| Isoda, Kenta| Kitada, Kouji| Hamano, Ryousuke| Nishie, Manabu| Tokunaga, Naoyuki| Tsunemitsu, Yousuke| Iwakawa, Kazuhide| Iwagaki, Hiromi|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Kimura, Yuji| Iwakawa, Kazuhide| Nishie, Manabu| Inagaki, Masaru| Iwagaki, Hiromi|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Hamano, Ryosuke| Inagaki, Masaru| Kimura, Yuuji| Isoda, Kenta| Kitada, Koji| Nishie, Manabu| Nomura, Nagahisa| Tokunaga, Naoyuki| Takahashi, Kenji| Miyasou, Hideaki| Tsunemitsu, Yosuke| Ohtsuka, Shinya| Miyoshi, Kazuya| Iwakawa, Kazuhide| Takahashi, Masahiko| Iwagaki, Hiromi|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author Miyasou, Hideaki| Iwakawa, Kazuhide| Inagaki, Masaru| Kimura, Yuuji| Nishie, Manabu| Hamano, Ryousuke| Tokunaga, Naoyuki| Tunemitsu, Yousuke| Otsuka, Shinya| Iwagaki, Hiromi|
Published Date 2012-04-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue1
Content Type Journal Article
Author Nishie, Manabu| Iwakawa, Kazuhide| Hamano, Ryousuke| Tokunaga, Naoyuki| Tunemitsu, Yousuke| Ootsuka, Shinya| Inagaki, Masaru| Iwagaki, Hiromi| Goubaru, Tomohiro| Fujita, Isao| Murakami, Takako| Tomoda, Jun|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Nishie, Manabu| Otsuka, Shinya| Tomoda, Jun| Fujiwara, Keishi|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Hamano, Ryosuke| Otsuka, Shinya| Kimura, Yuuji| Nishie, Manabu| Tokunaga, Naoyuki| Miyasou, Hideaki| Tsunemitu, Yousuke| Inagaki, Masaru| Iwakawa, Kazuhide| Iwagaki, Hiromi|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
Author Hamano, Ryosuke| Inagaki, Masaru| Nishie, Manabu| Tokunaga, Naoyuki| Tsunemitsu, Yosuke| Ohtsuka, Shinya| Iwakawa, Kazuhide| Iwagaki, Hiromi| Sonobe, Hiroshi|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
Author Hamano, Ryousuke| Otsuka, Shinya| Nishie, Manabu| Nomura, Tsunehisa| Tokunaga, Naoyuki| Miyasou, Hideaki| Takahashi, Kenji| Tsunemitsu, Yousuke| Miyoshi, Kazuya| Inagaki, Masaru| Iwakawa, Kazuhide| Takahashi, Masahiko| Iwagaki, Hiromi|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
Author Miyaso, Hideaki| Nishie, Manabu| Iwagaki, Hiromi| Ishii, Hiroo| Fujita, Isao| Tomoda, Jun|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
Author Hamano, Ryosuke| Inagaki, Masaru| Nishie, Manabu| Tokunaga, Naoyuki| Tsunemitsu, Yosuke| Ohtsuka, Shinya| Iwakawa, Kazuhide| Iwagaki, Hiromi| Sonobe, Hiroshi|
Published Date 2010-04-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue1
Content Type Journal Article
Author Nishie, Manabu|
Published Date 2009-09-30
Publication Title
Content Type Thesis or Dissertation
Author Hamano, Ryosuke| Ohtsuka, Shinya| Fujii, Sayaka| Nishie, Manabu| Tokunaga, Naoyuki| Tsunemitsu, Yosuke| Iwakawa, Kazuhide| Inagaki, Masaru| Ohsaki, Toshihide| Iwagaki, Hiromi|
Published Date 2009-12-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue3
Content Type Journal Article
Author Fujii, Sayaka| Nishie, Manabu| Hamano, Ryousuke| Tokunaga, Naoyuki| Tsunemitsu, Yousuke| Ootsuka, Shinya| Miyoshi, Kazuya| Takahashi, Masahiko| Inagaki, Masaru| Oosaki, Toshihide| Iwagaki, Hiromi|
Published Date 2009-04-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue1
Content Type Journal Article
Author Tsunemitsu, Yosuke| Inagaki, Masaru| Hamano, Ryosuke| Nishie, Manabu| Tokunaga, Naoyuki| Otsuka, Shinya| Osaki, Toshihide| Iwagaki, Hiromi|
Published Date 2008-08-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue2
Content Type Journal Article