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ID 16330
Eprint ID
16330
FullText URL
Thumnail 95_583.pdf 5.11 MB
Title Alternative
Effect of BCG and Levamisole on peritoneal invasion of cancer: experimental study in mice.
Author
Nishihara, Koichi
Abstract
An insight into the mechanism of cancer invasion through the serosa of digestive organs has not been obtained since an adequate experimental model has not been found. In this report, the mouse abdominal wall was considered as intestinal wall and the invasive pattern of cancer cells into the peritoneum was examined morphologically by means of scanning election microscopy (SEM). The effects of BCG and Levamisole (LMS) on the invasion and growth of cancer were also studied. When Ehrlich ascites tumor cells were implanted into the subcutaneous layer of the abdominal wall, the mesothelial cells became round, and the intercellular space expanded 7 days after the implantation. The tumor cells invaded the intercellular space by the 10th day. The mesothelial microvilli became dence and formed a meshwork 7 days after the tumor implantation in combination with an interperitoneal injection of BCG, resulting in firm intercellular binding. The condition was much more obvious on the 10th day. The enhancement of intercellular binding by BCG may play a role in preventing peritoneal invasion. Administering BCG before tumor implantation was better in preventing than administering it after the implantation. The most effective way was to administer BCG before the implantation, followed by two times a week from the 3rd day after the implantation. When LMS was used, the microvilli became quite dence, but not as much as with BCG. With administration of LMS from the 14th day after tumor implantation regression of tumor growth occurred, although the efficacy of LMS was less than that of BCG.
Keywords
漿膜浸潤
走査電顕
BCG
Levamisole
Published Date
1983-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
583
End Page
600
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/7-8/95_7-8_583/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma