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ID 16407
Eprint ID
16407
FullText URL
Thumnail 96_411.pdf 2.32 MB
Title Alternative
Analysis of serum thyrotropin dynamics after TRH stimulation in normal children
Author
Araki, Kumiko
Higuchi, Jouji
Kanzaki, Susumu
Katayama, Masahiro
Himoto, Yuusuke
Uchida, Yoshiyuki
Ogura, Takeo
Fujita, Chiharu
Kimoto, Hiroshi
Abstract
In order to establish the quantitative parameters indicating serum thyrotropin dynamics after TRH stimulation, we measured the maximum incremants in TSH above the baseline level (max. ⊿TSH), the percentage ratio of the TSH level at 30 min to that at 15 min (R 30/15) and the percentage ratio of the TSH level at 120 min to that at 30 min (R 120/30) in 145 normal children. The geometric means (-2SD and+2SD) of max. ⊿TSH, R 30/15 and R 120/30 were 11.2% (3.9 to 32.5) uU/ml, 101.1% (75.9 to 134.7) and 38.9% (25.8 to 58.5), respectively. The values were compared with those of variables computed from the mathema- tical model of Okuno et al. (1977), i.e., C=(a/(β-α))•(Q(0)/V)(e(-αt)-e(-βt)+Coe(-βt)where α=the rate constant for TSH release, β=the rate constant for TSH elimination, and Q(0)/V=the serum TSH releasing value per minute. Highly significant correlations were found between max. ⊿TSH and Q(0)/V (p<0.001), between R 30/15 and α (p<0.001) and between R 120/30 and β (p<0.001). The values of max. ⊿TSH also correlated well with the integrated secretion of TSH (p<0.001). These results suggest that our three parameters are more practical and useful indicators of serum TSH dynamics after TRH stimulation than the cumbersome mathematical model of Okuno et al. (1977), facilitating the detection of mild delayed TSH response.
Keywords
TRH 負荷試験
TSH
分泌動態解析
Published Date
1984-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
411
End Page
420
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/3-4/96_3-4_411/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma