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ID 15980
Eprint ID
15980
FullText URL
Thumnail 99_955.pdf 684 KB
Title Alternative
Studies on the Pathogenesis of Duodenal Ulcer from the Viewpoint of the Gastro-Pancreatic Secretory Relationship.2. Gastric Juice Secretion and Pure Pancreatic Juice Secretion in Response to Intraduodenal Acid Load.
Author
Hanafusa, Eiji
Abstract
To delineate stomach-pancreas interactions as related to the pathogenesis of duodenal ulcer, a comparison of gastric secretory function and exocrine pancreatic secretory function was made in controls, patients with gastric ulcer and those with duodenal ulcer. Gastric juice was aspirated through a Rehfuss tube before and after an injection of AOC-tetragastrin (4 μg/kg of body weight). Exocrine pancreatic function was determined by measuring the initial HCO(3) concentration (wash-out phase), HCO(3) output and maximal HCO(3) concentration of pure pancreatic juice collected endoscopically after intraduodenal instillation of hydrochloric acid (0.1 N, 100 ml). Serum secretin was also measured serially. Patients with duodenal ulcer showed significantly higher gastric acid secretion. They also showed significantly higher pancreatic HCO(3) output as well as higher initial HCO(3) concentration as in my previous study on exogenous secretin stimulation. A significant correlation was noted between gastric acid secretion and pancreatic HCO(3) secretion. However, the serum secretin response did not differ significantly among the three groups. These results indicate that patients with duodenal ulcer display a normal secretin release response to intraduodenal acid load and an augmented pancreatic bicarbobate secretion in response to the released secretin. These findings were discussed in relation to the pathogenesis of duodenal ulcer.
Keywords
胃膵分泌相関
十二指腸潰瘍
純粋膵液
胃液分泌
膵外分泌
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
955
End Page
969
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_955/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma