JaLCDOI 10.18926/AMO/32022
FullText URL fulltext.pdf
Author Liu, Li| Aya, Kunihiko| Tanaka, Hiroyuki| Shimizu, Junya| Ito, Shigeru| Seino, Yoshiki|
Abstract <p>Nephrin, a gene product of the congenital nephrotic syndrome of the Finnish type (NPHS1), is a 1242-residue putative transmembrane protein of the immunoglobulin family of cell adhesion molecules. The expression of this gene is localized in rat and human glomerular epithelial cells. Here we report the expression of nephrin in various tissues other than the kidneys in mice. The expression of nephrin mRNA in various tissues of mice, including the kidneys, testes, spleen, thymus and brain, were first investigated by the RT-PCR method, and it was shown that a high level of nephrin mRNA could be detected in the testes of mice 1-6 weeks old. In situ hybridization revealed the expression of the nephrin gene in the Sertoli cells. Additionally, immunofluorescent staining studies indicated that nephrin was colocalized with anchoring protein ZO-1 in the mouse testis. From these results, it is inferred that nephrin is an important component of the barrier system in testes.</p>
Keywords nephrin Sertoli cells glomerular epithelial cells blood barrier
Amo Type Article
Published Date 2001-06
Publication Title Acta Medica Okayama
Volume volume55
Issue issue3
Publisher Okayama University Medical School
Start Page 161
End Page 165
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11434428
Web of Sience KeyUT 000169512600002
Author Aya, Kunihiko|
Published Date 1997-12-25
Publication Title 岡山医学会雑誌
Volume volume109
Issue issue7-12
Content Type Journal Article
Author 綾 邦彦|
Published Date 1997-09-30
Publication Title
Content Type Thesis or Dissertation