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ID 16216
Eprint ID
16216
FullText URL
Thumnail 96_69.pdf 1.44 MB
Title Alternative
Studies on Complex-release Activity of Complememt in Systemic Lupus Erythematosus -Using Peroxidase as an Antigen in the Immune Complex- Part 2. Clinical Studies
Author
Aibara, Yasushi
Abstract
Complex-release activity (CRA) of complement was measured in 50 systemic lupus erythematosus (SLE) patients by a simplified method using peroxidase as an antigen in the immune complex. The relation between CRA and other complement levels was investigated, and the influence of CRA on the pathogenesis of SLE was discussed.CRA and ACRA (CRA via the alternative pathway) in SLE were lower than those in normal subjects. CRA and ACRA in SLE correlated well with CH50, ACH50, C3, C4 and factor B. The enhancement of CRA via the classical pathway in SLE was less strong than that in normal subjects. As reduced CRA normalized shortly after the administration of corticosteroid in some SLE patients with persistent hypocomplementemia, the measurement of CRA might be more useful than that of CH50 for clinical purposes. The above results suggest that the alternative complement pathway was activated by immune complexes in vivo and that CRA might play an important role in the clearance of immune complexes in vivo.
Keywords
全身性エリテマトーデス
immune complex
alternative complement pathway
可溶化現象
Published Date
1984-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
69
End Page
76
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/1-2/96_1-2_69/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma