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ID 52806
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Author
Ohnishi, Atsuyuki
Matsushita, Hiroshi
Matsumoto, Kazuyuki
Yasunaka, Tetsuya
Koike, Kazuko
Abstract
Background/Aims: In patients with septic shock, the degree of liver dysfunction is correlated with serum levels of soluble intercellular adhesion molecule (sICAM)-1. We aimed to assess the usefulness of serum levels of soluble adhesion molecules as prognostic factors for acute liver failure (ALF). Methods: Serum levels of soluble platelet endothelial cell adhesion molecule (sPECAM)-1, sICAM-3, soluble endothelial (sE) selectin, sICAM-1, soluble platelet selectin, and soluble vascular cell adhesion molecule-1 on admission were measured in 37 ALF patients and 34 healthy controls. Results: Twenty-two ALF patients (59%) reached to fatal outcomes. Serum levels of sPECAM-1, sICAM-3, sE-selectin and sICAM-1 were higher in ALF patients than healthy controls. In 37 ALF patients, by the multivariate logistic regression analysis, ratio of direct to total bilirubin (per 0.1 increase; OR 0.11, 95% CI 0.01-0.99), serum sPECAM-1 level (per 100 ng/ml increase; OR 4.37, 95% CI 1.23-15.5) and serum sICAM-1 level (per 100 ng/ml increase; OR 0.49, 95% CI 0.27-0.89) were associated with fatal outcomes. Using receiver operating characteristics curve, each area under the curve of serum sPECAM-1 and sICMA-1 levels as prognostic factors was 0.71 and 0.74, respectively. Conclusion: Serum sPECAM-1 and sICAM-1 levels may be useful for predicting the prognosis of ALF.
Keywords
Acute liver failure
Intercellular adhesion molecule-1
Liver transplantation
Platelet endothelial cell adhesion molecule-1
Prognosis
Published Date
2012
Publication Title
Digestion
Volume
volume86
Issue
issue2
Start Page
122
End Page
128
ISSN
0012-2823
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52531
language
英語
Copyright Holders
(c) 2012 S. Karger AG, Basel
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author
Refereed
True
DOI
Web of Sience KeyUT