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ID 42614
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Title Alternative
Lymphagogue Action of Extract of Lobster Muscle Due to Liberation of Adenine Nucleotides
Author
Kamimura, Yukio
Tasaka, Kenji
Nishijima, Katsumi
Kume, Masao
Abstract
The lymphagogue effect of extract of lobster muscle, which is one of the first class of HEIDENHAIN'S lymphagogues, is essentially the action of adenine nucleotides liberated from the tissues by the injection of this extract. And also it is proven that these nucleotides are liberated in a larger quantity from organs in other parts of the body rather than from viscera. This conclusion is based on the following evidences. 1) Systemic-venous injection of the extract accelerate the outflow of a uncoagulable, highly proteinized lymph from the thoracic duct of dog, accompanied by a fall in arterial blood pressure and a rise in portal pressure. All these phenomena are also observable by the intravenous injection of adenosine triphosphate (ATP). 2) Repeated injections weaken the reactions to this extract (Tachyphylaxis). 3) Immediately after vascular administration of the extract adenine nucleotides including ATP are detected in blood plasma spectrophotometrically as well as paperchromatographically. Quantitatively the content in nucleotides is higher in the plasma from the femoral vein after systemic-venous injection than from the hepatic vein after portal injection. 4) No definite increase of histamine in blood can be recognized after systemic-venous injection of the extract.
Published Date
1957-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2035
End Page
2047
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/8/69_8_2035/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma