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ID 15871
Eprint ID
15871
FullText URL
Thumnail 99_169.pdf 1.09 MB
Title Alternative
Experimental study of the hepatic accumulation of the immune complex and its hepatocytotoxity
Author
Watanabe, Masahiro
Abstract
It was studied whether IgG-immune complexes were taken up by liver parenchymal cells and whether liver injury was induced by the immune complexes. When asialoorosomucoid, orosomucoid and human serum albumin immune complexes at various antigen-antibody ratios were infused into the portal vein of rats, the antibody-excess immune complexes were partly taken up by liver parenchymal cells via the asialoglycoprotein receptor. However, liver injury was not caused by the immune complexes. These observations suggest that 1) immune complexes at certain antigen-antibody ratios bind to the asialogycoprotein receptor, 2) immune complexes bound to the asialoglycoprotein receptor do not activate the complement system and 3) a transient increase in plasma immune complexes does not induce liver injury.
Keywords
免疫複合体
アシアロ糖蛋白質受容体
肝障害
Published Date
1987-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
169
End Page
178
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/1-2/99_1-2_169/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma