このエントリーをはてなブックマークに追加
ID 19054
Eprint ID
19054
FullText URL
Thumnail 70_2285.pdf 323 KB
Title Alternative
Nitrogen Metabolism of the Brain Part 11 Ammonia and Amino Acid Contents of the Rat Brain in Case of the NH(4)Cl Application
Author
Kawata, Saburo
Abstract
In case of the intraperitoneal application of ammonium chloride, ammonia of the rat brain was measured by Conway's microdiffusion method, and amino acid by paperchromatography; the following results were obtained. 1) During the ammonium chloride convulsions (induced by injection of 1ml. of 10% NH(4)Cl), the ammonia and aspartic acid contents of the rat brain increased remarkably, while glutamic acid, glutamine and γ-amino butylic acid contents decreased. 2) Ammonia and amino acids were estimated in 3 hours after NH(4)Cl injeetion (1ml. of 5% NH(4)Cl), and the following data were obtained. a. Ammonia level remarkably rose five minutes after injection, and gradually returned to normal level 3 hours after. b. Glutamic acid decreased. c. The rise of glutamine level found 10 minutes to 1 hour after the application. d. γ-amino butylic acid decreased. e. Aspartic acid level rose on early period. The Conclusion is as follows: 1) In the rat brain, the free ammonia increased after NH(4)Cl injection. 2) Ammonia increased after NH(4)Cl injection was probably reduced, initially by aspartie acid synthetase system and thereafter by glutamine synthetase syestm.
Published Date
1958-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2285
End Page
2289
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/6/70_6_2285/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma