岡山医学会 Acta Medica Okayama 0030-1558 78 2-3 1966 肝循環動態に関する研究　第1編 肝疾患時における肝内酸素消費に関する研究 201 210 EN Hiroyuki Hashimoto By means of catheterization of hepatic veins, hepatic oxygen consumption was estimated on patients with chronic viral hepatitis (37 cases), precirrhosis (4 cases) and cirrhosis of the liver (13 cases). The oxygen consumption was calculated from the difference of oxygen content between the hepatic artery and the hepatic vein multiplied with the total hepatic blood flow. The results werc as follows: 1. The oxygen content of the arterial blood showed no significant difference in groups of chronic hepatitis, precirrhosis and cirrhosis of the liver. 2. Similarly, the arterio-venous oxygen difference, as measured without any regard of hepatic shunt flow, did not differ significantly in those three groups. Decreased hepatic blood flow, therefore induced a decreased amount of hepatic oxygen consumption; the decrease of hepatic blood flow was not accompanied with the compensatory increase of the plausible arterio-venous oxygen difference. 3. The arterio-venous oxygen difference calculated with a reference to the influences of hepatic shunt flow was estimated by multiplication of arterio-venous oxygen difference to the ratio of total hepatic blood flow and effective hepatic blood flow. The difference was found to be increased in a majority of the cases of liver cirrhosis, indicating the oxygen extraction by the hepatic cells in cirrhosis was significantly increased. Conversely, oxygen saturation of non-shunted hepatic venous blood was markedly decreased in cirrhosis. Thus the increased oxygen extraction by the cirrhotic hepatic cells occured in the state of low oxygen tension. The hepatic oxygen consumption was found to be maintained as great as possible by increasing the arterio-venous oxygen difference calculated with a reference to the influence of hepatic shunt flow. 4. The increase of the arterio-venous oxygen difference calculated with a reference to the influence of hepatic shunt flow was closely related to the abnormalities of the hepatic hemodynamics, histological changes and hepatic disfunctions. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 78 2-3 1966 肝循環動態に関する研究　第2編 肝リンパに関する研究-実験犬による検討 211 225 EN Hiroyuki Hashimoto To study dynamics and physico-chemical properties of the hepatic lymph of normal dogs, cannulation of hepatic lymph duct was performed under nembutal anesthesia, and the lymph flowing out of the fistula was continuously collected. Similar experiments were also carried out on dogs with acute carbon tetrachloride poisoning. The results were as follows. 1. The average rate of hepatic lymph flow was 1.52cc per 10 minutes (0.07cc per 10 minutes per kilogram) in normal mongrel dogs. 2. In dogs with acute carbon tetrachloride poisoning, not only the average rate of hepatic lymph flow but also the pressure and the diameter of lymphatic vessels of the liver was remarkably increased. 3. More or less cellular elements, mainly lymphocytes, even some red blood cells, were detected in the liver lymph of intact dogs. A marked increase of red blood cells were observed in the lymph of dogs with acute carbon tetrachloride poisoning. This fact indicated that the lymph-canaliculus of the liver was open to red blood corpuscles in part, and this phenomenon was manifested by carbon tetrachloride poisoning. 4. The liver lymph contained approximately similar amount of protein to the serum and all the protein fractions as observed in the serum. The A/G quotient was usually higher in the liver lymph than in the serum. These data would suggest that all fractions of seum protein are able to leak out from the sinusoid walls and enter the lymphatic system of the liver. Furthermore, albumin produced by the hepatic cells may directly enter this lymphatic system. 5. The hepatic lymph contained a greater amount of glucose than serum, whereas the amount of bilirubin, cholesterol and alkaline phosphatase in hepatic lymph was smaller than that in serum. The results are of interest when the transfer of metabolites between hepatic cells and lymph or blood is considered. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 78 2-3 1966 高利得心電図について 227 234 EN Syoichi Haraoka Michihiko Sato Hiroshi Shiina Akira Itani Hiroyuki Hashimoto A newly developed augmented electrocardiogram was tested. (xlO) Using this electrocardiogram. the P wave, PR interval and QT duration were studied. Utilization of the augmented electrocardiogram was reported. No potential conflict of interest relevant to this article was reported.

Acta Medica Okayama 1966 肝循環動態に関する研究 EN Hiroyuki Hashimoto No potential conflict of interest relevant to this article was reported.