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ID 17499
Eprint ID
17499
FullText URL
Thumnail 87_949.pdf 1.02 MB
Title Alternative
Effects of vaso-active peptides on the excitability of identified molluscan giant neurones
Author
Takeuchi, Hiroshi
Mori, Akitane
Yokoi, Isao
Abstract
Two spontaneous firing giant neurones (TAN, tonically oscillating neurone and PON, periodically oscillating neurone) were identified in the subesophageal ganglia of Achatina fulica Ferussac. Effects of vaso-active peptides (substance P, physalaemin, eledoisin-related substance, neurotensin, bradykinin (B.K.), Lys-B.K., Met-Lys-B.K., angiotensin (A.G.) Ⅰ, A.G. Ⅱ, hypertensin, A.G. Ⅲ) were examined on the excitability of these two neurones. Physalaemin showed the excitatory effect on the TAN excitability. This effect was due to depolarizing the TAN neuromembrane. The critical concentration (in bath application) was about 5x10(-5)g/ml. All of amino acids, of which physalaemin consists, were ineffective on the TAN excitability. The other mentioned peptides than physalaemin were ineffective on the same neuromembrane. All of peptides examined in the present work were ineffective on the PON excitability. Effects of vaso-active peptides are considered to be selective in the neuronal level.
Published Date
1975-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume87
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
949
End Page
953
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/87/11-12/87_11-12_949/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma