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ID 19316
Eprint ID
19316
FullText URL
Thumnail 71_1563.pdf 404 KB
Title Alternative
Studies on the TCA cycle in Brain mitochondria Part Ⅱ, On the non-epileptic and epileptic brain mitochondria
Author
Higuchi, Shinnosuke
Abstract
The respiration of human brain mitochondria was measured by the Warburg's manometer and the members of the TCA cycle were used as the substrate. The O(2)-uptake of the non-epileptic brain mitochondria is about on and half times of the epileptic brain mitochondria. On the oxidation of the substrate: Malate, fumarate, pyruvate, oxalacetate and α-ketoglutarate accelerate the O(2)-uptake in both cases, and the O(2)-uptake of non-epileptic cases are always 2 or 3 times of the epileptic cases. Citrate accelerate the O(2)-uptake in the non-epileptic case, but not in the epileptic case. Succinate accelerate the O(2)-uptake in both cases and its about several times of the other substrate. Especially the increase of the O(2)-uptake of the epileptic brain mitochondria by succinate is higher than of the non-epileptic brain mitochondria.
Published Date
1959-03-15
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue3-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1563
End Page
1570
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/3-2/71_3-2_1563/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma