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ID 14475
Eprint ID
14475
FullText URL
Thumnail 104_581.pdf 3.04 MB
Title Alternative
Response of luteinizing hormone and follicle stimulating hormone to luteinizing hormone-releasing hormone in prepubertal and pubertal chidren, as measured by a highly sensitive immunradiometric assay
Author
Higuchi, Joji
Abstract
To investigate the age-related changes in the pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH), the consentrations of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured before and after LH-RH administra-tion using the highly sensitive immunoradiometric assay (IRMA) in 283 normal children (161 males and 77 females) between 4 and 14 years old and in 22 patients (18 males and 4 females) with pituitary dwarfism. Then, the area of response above the basal level [integrated response(Σ)] of LH and FSH during 60 minutes after LH-RH injection was calculated to evaluate the pituitary response to LH-RH. The integrated LH responses progressively increased in the boys from 8 years of age and in the girls from 6 years of age, and they continued to increase up to 14 years of age. The integrated FSH response showed a significant decrease in all grups in the girls, but did not show any change in the boys. In patients with pituitary dwarfism who were subsequently found to be gonadotropin deficient, the level of Σ LH60 was low (below-2SD) It is concluded that integrated responses of gonadotropins, especially LH, to LH-RH are useful to evaluate the maturation of the hypothalamic-pituitary-gonadal axis, and that incre-ment of LH responsiveness to LH-RH already begins before the onset of puberty. The peak appearance time of gonadotropins after LH-RH is also important in the assessment of the maturation of the hypothalamic-pituitary-gonadal axis because FSH reached its peak carlier in the pubertal group than in the prepubertal group.
Keywords
LHRH
LH
FSH
下垂体性小人症
ゴナドトロピン分泌不全
Published Date
1992-12
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
581
End Page
590
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/104/5-6/104_5-6_581/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma