JaLCDOI 10.18926/40360
Title Alternative Studies of the radio-active springs : XXIV Effect of the internal use of the radio-active waters on alimentary hyperglycemia, influence cf the aging of mineral water
FullText URL rbl_003_015_017.pdf
Author Morinaga, Hiroshi|
Publication Title 放射能泉研究所報告
Published Date 1950-07-25
Volume volume3
Start Page 15
End Page 17
language 日本語
File Version publisher
NAID 120002484884
JaLCDOI 10.18926/40343
Title Alternative STUDIES ON VITRIOL SPRINGS (3) EFFECT OF THE INTERNAL USE OF VITRIOL WATER OF FUJINO ON THE GASTRIC ACIDITY
FullText URL pitsr_013_009_014.pdf
Author Morinaga, Hiroshi|
Abstract Fujino Spring is the foremost acid vitriol spring of Japan in ferrous and ferric ion contents. Six years ago the author reported that its internal use had an remarkable hemopoietic effect on hypochromic anemia and delayed the curve of alimentary hyperglycemia in rabbit. Twenty ml. of this vitriol water was diluted with plain water to two hundred ml. and was given to twenty one patients by stomach tube at 37°C. Gastric acidity of the patients was measured at 30 minutes intervals during the following 150 minutes after the administration of the water. In six cases of normal acidity no significant difference was proved between the effects of the mineral water and of caffein control (0.2g. in 200 ml.). In six cases of hyperacidity it seemed that the vitriol water decreased in the acidity curve compared with control. In nine patients of hypo- and anacidity both free and total acidity curve was elevated by the use of the mineral water compared with caffein control. The internal use of Fujino Spring in moderate dilution with plain water regulated the gastric acidity.
Publication Title 岡山大学温泉研究所報告
Published Date 1953-12
Volume volume13
Start Page 9
End Page 14
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002484879
JaLCDOI 10.18926/40332
Title Alternative MEDICAL STUDIES ON THE RURAL PEOPLE (II) A STUDY ON THE INCIDENCE OF STRUMA IN THE SOUTH-WESTERN RURAL DISTRICTS OF OKAYAMA PREFECTURE, JAPAN
FullText URL pitsr_014_051_056.pdf
Author Morinaga, Hiroshi|
Abstract The author investigated the thyroid glands of 1480 school children (aged from 6 to 14) living in the vicinity of Yakage, the south-western rural district of Okayama Prefecture, and 1516 out-patients of Yakage Hospital, in 1950. The incidence of struma among the school children was 4.6 per cent and among the out-patients 4.7% on an average, and the percentage of struma in the spring (7.8%) was higher than in the summer (2.98%). This result suggests that thyroid glands are in some way susceptible to seasonal influences, and it is therefore necessary to consider the effect of season during investigation. The white blood pictures of seven patients showed no specific findings.
Publication Title 岡山大学温泉研究所報告
Published Date 1954-03
Volume volume14
Start Page 51
End Page 56
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002462907
JaLCDOI 10.18926/40331
Title Alternative MEDICAL STUDIES ON THE RURAL PEOPLE (I) CLINICAL AND STATISTICAL OBSERVATIONS ON HOOKWORM DISEASE IN RURAL DISTRICTS
FullText URL pitsr_014_045_050.pdf
Author Morinaga, Hiroshi|
Abstract The author studied statistically 160 cases of hookworm infection who had been admitted to Misasa Branch of Okayama University Hospital, Misasa Hot Springs in Tottori prefecture, during 1946~1949 and 162 cases of out-patients with anchylostomiasis in Yakage Hospital, Okayama Prefecture, during 1949~1950. The clinical findings were as follows: (1). Females showed a higher incidence than males and the incidence ratio of infected persons to total out-patients increased with age up to the 50~69 years group. (2). The most patients consulted our hospital for the first time in April~May and in August, and 62 per cent of cases came within 3 months scince they had noticed disorders in some way, but 22% remained at home without medical cure more than a year. (3). Chief subjective complaints were palpitation of heart (35.3%), lassitude of legs (31.2%), pains in the abdomen (22.9%), feeling of dizziness (21.6%) and so on. (4). Laboratory findings: The total number of erythrocytes was between 1.23 and 5.54 millions per cubic millimeter and a moderate anemia almost always developed in the hookworm disease (77.9% of all cases). The number of white cells was normal or slightly increased. Relative or absolute eosinophilia was recognized in 83.5% of all patients. Wassermann's test was positive in 20%, and Takata's reaction positive in 53% of the cases. The acidity of the gastric juice was lower than normal. Hypo- and anacidity were verified in 58%. Both albumen and urobilinogen test in urine were positive in 5.4% of 61 cases. Sugar in none. (5). Treatment: Thymol, tetrachlorethylene and oil of chenopodium were used alternately to remove the worms. The eggs in stool became negative after 3-4 times of the administration of anthelmintics in 76 per cent of 151 cases. As mentioned above, the patients infected with hookworm had various functional disorders of bodies, but they consulted the hospital only when the farmer's busy season began and their trouble became unbearable. And then the recovery of anemia took a month or two. Prof. Kitayama reported that the cold environment under 9°C. in the winter had perished the larva of hookworm in the soil. From these viewpoints, the author proposed that examination and cure of hookworms should be carried out in the winter, the slack season for farming, to prevent the fall of working ability due to anchylostomiasis during the busy farming seasons.
Publication Title 岡山大学温泉研究所報告
Published Date 1954-03
Volume volume14
Start Page 45
End Page 50
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40330
language 日本語
File Version publisher
NAID 120002462906
JaLCDOI 10.18926/40326
Title Alternative ASOZU (WEAK COMMON SALT SPRING), HAMAMURA (SULPHATED BITTER SPRING), KAlKE (CALCIUM CHLORIDE CONTAINING SALINE SPRING) AND FUJINO (ACID ALUM VITRIOL SPRING) SPRING WATERS AND THE ALIMENTARY HYPERGLYCEMIA
FullText URL pitsr_014_022_029.pdf
Author Morinaga, Hiroshi|
Abstract There are many experimental reports and clinical observations about the internal use of thermal waters on carbohydrate metabolism, and alkaline springs, alkaline common salt springs and sulphur springs are used for the balneological therapy of diabetic patients. The author reported that the internal use of the radon springs of Japan, such as Misasa, Ikeda and Masutomi thermal waters promoted the action of insuline and inhibited the experimental hyperglycemia in rabbits, and he suggested that these radioactive waters also would be able to utilize for the diabetic treatment. On the other hand, trace elements such as Cu, Zn and Mn have protective effects against disturbed carbohydrate metabolism of diabetic body. Some thermal waters contain these trace elements in various degrees, and Oshima & Ashizawa observed that after the drinking of Fujino mineral water the iron, copper, nickel and cobalt content in blood rose temporarily. In this report, the author investigated the influence of the drinking of Asozu (weak common salt spring), Hamamura (sulphated bitter spring), Kaike (calcium chloride containing saline spring) and Fujino (acid alum vitriol spring) Spring waters upon the alimentary hyperglycemia in rabbits. Thirty ml. of 10% glucose solution in thermal water (Fujino Water was diluted twice with plain water) or in plain water per kg. of bodyweight was administered to the rabbit by stomach tube and blood sugar level was determined before, 1/2, 1, 2, 3 and 4 hours after the administration. The results were as follows: 1. The drinking of Asozu Spring water inhibited the alimentary hyperglycemia compared with the plain water as a control. 2. Hamamura Spring had a tendency to decrease the blood sugar level. 3. Kaike Spring water had no inhibitory a.ction upon the alimentary hyperglycemia. 4. In spite of the existence of trace elements, Fujino mineral water had no significant effect. The author supposed that this was due to its high acidity.
Publication Title 岡山大学温泉研究所報告
Published Date 1954-03
Volume volume14
Start Page 22
End Page 29
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002462903
JaLCDOI 10.18926/40322
Title Alternative THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I)
FullText URL 016_035_048.pdf
Author Morinaga, Hiroshi|
Abstract The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)~455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55~90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2~6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30~3.47mg./dl. , 5% rejection limit -- 1.97~3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78~108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 35
End Page 48
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language 日本語
File Version publisher
NAID 40017532470
JaLCDOI 10.18926/40321
Title Alternative SEASONAL VARIATION OF GASTRIC ACIDITY
FullText URL pitsr_016_031_034.pdf
Author Morinaga, Hiroshi|
Abstract Since, in Japan situated in the temperate zone, climatic change through the four seasons of a year is regular, it is expected that there the physiological reactions of the human body may vary regularly in accordance with the climatic change. In fact, we experience that the attacks of diseases and their conditions are in close connection with the changes of the seasons. The author investigated the effect of the seasons upon the human gastric acidity, by means of the coffein-test, in 580 cases with gastrointestinal disorders, at the Misasa Branch Hospital of Okayama University, Misasa Spa in Tottori Prefecture, in 1946~1946. Hyperacidity was verified in 194 (33%) of 580 cases, normacidity in 134 (23%), anacidity in 138 (24%) and hypacidity in 114 (20%). The percentage of hyperacidity increases in winter (41%), decreases in spring (32%) and in summer (28%), and increases again in autumn (34%). The cases of anacidity decrease in winter and spring, but increase in summer. In chi-square test, the season and the acidity of gastric juice were taken as factors of variation. The chi-square was computed with the result: Pr {X(3)=14.013<16.919} =5%, so it cannot be asserted that the seasonal changes effect the acidity of gastric juice. But if Comparison is made between summer and winter with respect to the anacidity-hypacidity vs. the hyperacidity, the author: obtains Pr {X(2)=6.06> 5.412} =2%. It is thus verified that the cases of hyperacidity predominate over those of anacidity-hypacidity in winter, while the relation is reverse in summer. As was mentioned above, the tendency is obvious that the acidity of gastric juice decreases in summer and increases in winter. It was found that there is a regular seasonal variation in gastric acidity.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-01
Volume volume16
Start Page 31
End Page 34
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40318
language 日本語
File Version publisher
NAID 120002462901
JaLCDOI 10.18926/40313
Title Alternative EFFECT OF INTERNAL USE OF THERMAL WATER OF YUMURA AND MUSASHI HOT SPRINGS UPON THE ALIMENTARY HYPERGLYCEMIA IN RABBITS
FullText URL pitsr_017_008_012.pdf
Author Morinaga, Hiroshi|
Abstract The author investigated the effect of the internal use of thermal water of Yumura (weak alkaline spring, Hyogo Prefecture) and Musashi (weak common salt spring, Fukuoka Prefecture) Springs upon the alimentary hyperglycemia in rabbits. Sixty ml. of spring water, and of plain water as control, with 10% glucose in solution was administered to rabbits by stomach tube, and the blood sugar level was determined before and 1/2, 1, 2 and 3 hours after the administration. In all cases, the thermal water was revealed to inhibit the alimentary hyperglycemia significantly by comparing the results obtained with the thermal water and those with the plain water control.
Publication Title 岡山大学温泉研究所報告
Published Date 1956-03
Volume volume17
Start Page 8
End Page 12
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002462898
JaLCDOI 10.18926/40189
Title Alternative Medical studies on the rural people (3). Incidence rate of hypertension in rural districts, Tottori Prefecture, Japan
FullText URL pitsr_037_037_042.pdf
Author Inoue, Masakatsu| Morinaga, Hiroshi|
Abstract The authors examined the blood pressure levels of 5, 358 out-patients of Branch Hospital of Okayama University Hospital, Tottori Prefecture, during the four-year period, from April, 1957 to March, 1961. The following results were obtained: I. The incidence of hypertension with a systolic blood pressure over 150 mmHg was 20.5% (1,093 cases of 5,358). 2. Patients with hypertension over 40 years of age was 35.9% in male and 41.5% in female. Females showed a higher incidence than males and the incidence rate of hypertension increased with age. 3. There was a tendency in the incidence rate of patients with hypertension decreased in summer and increased in cold seasons.
Publication Title 岡山大学温泉研究所報告
Published Date 1967-12-15
Volume volume37
Start Page 37
End Page 42
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002400930
Author Inoue, Taeko| Ikegami, Tadaoki| Morinaga, Hiroshi|
Published Date 1970-03-30
Publication Title 岡山大学温泉研究所報告
Volume volume39
Content Type Data or Dataset
JaLCDOI 10.18926/40170
Title Alternative Study on the conbined therapy of spa and gold salt in rheumatoid arthritis Part II. An experience of granulocytopenia possibly caused by gold salt preparation
FullText URL pitsr_039_037_042.pdf
Author Ikegami, Tadaoki| Yahata, Takaaki| Kitayama, Minoru| Morinaga, Hiroshi|
Abstract A thirty seven years old woman with rheumatoid arthritis was instituted gold salt intramuscularly twice a week on the nineteenth hospital day. On the fifty fourth day, however, it was discontinued at the total dosis of 180 mg because of the skin rush. In about ten days after stopping gold injection appeared high fever with shivering and granulocytopenia was demonstrated. With immediate administration of ACTH, adrenocortical hormons etc. including blood transfusion the abnormal findings of the blood pictures returned to normal and the patient became well. Recently, gold salts are so widely used in treatment of rheumatoid arthritis as one of specific antirheumatic agents that the possible severe side effect such as granulocytopenia, if quite rare, should always be considered in the course of gold therapy.
Publication Title 岡山大学温泉研究所報告
Published Date 1970-03-30
Volume volume39
Start Page 13
End Page 35
ISSN 0369-7142
language 日本語
File Version publisher
Author Inoue, Taeko| Morinaga, Hiroshi|
Published Date 1972-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume41
Content Type Data or Dataset
JaLCDOI 10.18926/40142
Title Alternative A case of systemic lupus erythematosus with idiopathic thrombocytopenic purpura
FullText URL pitsr_042_025_029.pdf
Author Ichikawa, Yukinobu| Ikegami, Tadaoki| Kitayama, Minoru| Morinaga, Hiroshi|
Abstract A 24-year-old woman was presented in whom thrombocytopenic purpura appeared during antiinflammatory drugs therapy for arthralgia. At that time she had a positive LE cell preparation, positive antinuclear factor and false positive serum test for syphilis. Steroid hormon and ACTH therapy were started under the diagnosis of systemic lupus erythematosus. In the 23-rd hospital days, she had a negative LE cell preparation, negative antinuclear factor and negative serum test for syphilis. In the 28-th days after stopping steroid hormon and ACTH therapy, positive LE cell preparation and positive antinuclear factor appeared again.
Publication Title 岡山大学温泉研究所報告
Published Date 1973-03-25
Volume volume42
Start Page 25
End Page 29
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002398146
JaLCDOI 10.18926/40077
Title Alternative A FORTRAN data processing system for the epidemiological data on rheumatic diseases - Part 1. Basic programs for deposit and retrieval of data
FullText URL 046_045_059.pdf
Author Itoh, Keiko| Kitayama, Minoru| Morinaga, Hiroshi| Matsui, Yoshito|
Abstract A set of FORTRAN programs for small computer is described for deposit and retrieval of the epidemiological data, which have been compiled at the Kami-hojo-cho district in Feb. 1972and Feb. 1975. A data file is constructed on a magnetic disk. The following items are recorded and registered on the disk for every person: identification number, full name in Japanese alphabet, sex, date of birth, weight, height, blood pressures, chemical characterics of blood serum and urine, and various complaints of clinical significance (fever, morning stiffness, arthralgia, joint swelling, myalgia, cutaneous rash, aphthous stomatitis, dry eyes, dry mouth, joint deformity, subcutaneous nodules, lymph and parotid gland enlargement, struma, heart murmur, and neulogical findings). All information per one person requires only two IBM cards due to compact encoding of original records. The encode-decode procedures are explained also in the text.
Publication Title 岡山大学温泉研究所報告
Published Date 1977-03-25
Volume volume46
Start Page 45
End Page 59
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40000321122
JaLCDOI 10.18926/21313
Title Alternative Balneotherapy of gout
FullText URL pitsr_035_067_074.pdf
Author Morinaga, Hiroshi|
Publication Title 岡山大学温泉研究所報告
Published Date 1965-10-25
Volume volume35
Start Page 67
End Page 74
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311030
Author Morinaga, Hiroshi|
Published Date 1965-10-25
Publication Title 岡山大学温泉研究所報告
Volume volume35
Content Type Others
Author Inoue, Taeko| Morinaga, Hiroshi|
Published Date 1976-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume45
Content Type Data or Dataset
JaLCDOI 10.18926/21195
Title Alternative The treatment of rheumatoid arthritis with D-penicillamine. Preliminary report
FullText URL pitsr_047_069_075.pdf
Author Ishii, Hirofumi| Takasugi, Kiyoshi| Kitayama, Minoru| Morinaga, Hiroshi|
Abstract Twenty patients with classical or definite rheumatoid arthritis were treated with D-Penicillamine. Favorable responses were observed in 75% of the patients. Significant improvement in clinical parameters, such as ESR, CRP, titers of rheumatoid factor and so forth, was noticed in twenty weeks of treatment. Withdrawal from penicillamine treatment was necessitated in four patients because of adverse reactions to the drug. Untoward effects included skin rash (most frequent), pruritis and loss of taste. From this preliminary study we presume that in earlier cases in which rheumatoid lesions may be reversible, more favorable clinical effects would be expected from this agent.
Publication Title 岡山大学温泉研究所報告
Published Date 1978-03-25
Volume volume47
Start Page 69
End Page 75
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310960
Author Inoue, Taeko| Morinaga, Hiroshi|
Published Date 1979-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume48
Content Type Data or Dataset
JaLCDOI 10.18926/21181
Title Alternative A case of SLE with non-erosive joint deformity -Jaccoud's type arthropathy-
FullText URL 048_043_048.pdf
Author Tanaka, Juntaro| Domyo, Michihiro| Takasugi, Kiyoshi| Irino, Shozo| Morinaga, Hiroshi|
Abstract A case of SLE in a twenty-eight year old woman, who had polyarthritis with non-erosive joint deformity, was reported. Differential diagnosis in this case included (1) rheumatoid arthritis (2) postrheumatic fever arthritis (Jaccoud's arthritis) and (3) the overlap syndrome between SLE and rheumatoid arthritis. Laboratory findings on this patient and review on literature, however, strongly suggested that this lady had been suffering from Jaccoud's type arthropathy of SLE. Corticosteroid therapy was initiated and the clinical course of the patient thereafter has been more than favorable.
Publication Title 岡山大学温泉研究所報告
Published Date 1979-03-25
Volume volume48
Start Page 43
End Page 48
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40000321139