Author Okada, Yoshiki| Abe, Nobuhiro| Hisamori, Noriyuki| Kaneeda, Toshiaki| Moriyama, Shigeaki| Ohmori, Hitoshi| Mizutani, Masayoshi| Yanai, Hiroyuki| Nakashima, Yoshio| Yokoyama, Yusuke| Ozaki, Toshifumi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54825
JaLCDOI 10.18926/AMO/54505
FullText URL 70_4_285.pdf
Author Tanaka, Takashi| Gobara, Hideo| Inai, Ryota| Iguchi, Toshihiro| Tada, Akihiro| Sato, Shuhei| Yanai, Hiroyuki| Kanazawa, Susumu|
Abstract We present a case of a 66-year-old man with esophageal carcinoma. 18Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for evaluating distant metastasis and staging revealed 18F-FDG uptake in the third lumbar vertebra and other vertebrae. Magnetic resonance imaging could not differentiate bone metastases from benign bone lesions. We considered the possibility of bone marrow reconversion. 111Indium chloride (111In-Cl3) scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed erythroid bone marrow components in the bone lesions. The diagnosis of bone marrow reconversion was pathologically confirmed by a bone biopsy of the third lumbar vertebra. The patient underwent esophagectomy and has remained disease-free in the 2 years since. To the best of our knowledge, this is the first report to describe the usefulness of 111In-Cl3 with SPECT/CT for the diagnosis of bone marrow reconversion.
Keywords 111Indium chloride scintigraphy SPECT/CT bone marrow reconversion 18F-FDG PET/CT bone metastasis
Amo Type Case Report
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 285
End Page 289
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549674
Web of Sience KeyUT 000384748600009
JaLCDOI 10.18926/AMO/54423
FullText URL 70_3_223.pdf
Author Ebara, Shin| Kobayashi, Yasuyuki| Sasaki, Katsumi| Araki, Motoo| Sugimoto, Morito| Wada, Koichirou| Fujio, Kei| Takamoto, Atsushi| Watanabe, Toyohiko| Yanai, Hiroyuki| Nasu, Yasutomo|
Abstract The present case report describes a case of recurrent and advanced urachal carcinoma including neuroendocrine features with iliac bone metastasis after partial cystectomy and adjuvant chemotherapy consisting of irinotecan and cisplatin in a 32-year-old man. He received gemcitabine/cisplatin/ paclitaxel (GCP) combination chemotherapy, consisting of gemcitabin (1,000mg/m2) on day 1, 8, cisplatin (70mg/m2) on day 1, and paclitaxel (80mg/m2) on day 1 and 8. After three cycles of chemotherapy, PET-CT showed complete regression of the disease. So the patient underwent total cystourethrectomy, and histological examination showed an almost complete pathological response. External beam radiation therapy was also given to the ileac bone metastasis regions. However, PET-CT taken 17 months after the external beam radiation showed multiple lung metastases. He received GCP chemotherapy again, which resulted in a complete response again after three cycles of chemotherapy. This is the first report on GCP chemotherapy used not only as a salvage chemotherapy but also as a rechallenge regimen for metastatic urachal cancer including a neuroendocrine component.
Amo Type Case Report
Published Date 2016-06
Publication Title Acta Medica Okayama
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 223
End Page 227
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339213
Web of Sience KeyUT 000379406100011
JaLCDOI 10.18926/AMO/53341
FullText URL 69_2_119.pdf
Author Terasaka, Tomohiro| Hagiya, Hideharu| Kimura, Kosuke| Nada, Takahiro| Nakamura, Eri| Hanayama, Yoshihisa| Sugiyama, Hitoshi| Kobayashi, Yasuyuki| Yanai, Hiroyuki| Otsuka, Fumio|
Abstract We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.
Keywords catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension
Amo Type Case Report
Published Date 2015-04
Publication Title Acta Medica Okayama
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 122
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899634
Web of Sience KeyUT 000353181700007
Author Yanai, Hiroyuki|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Tanabe, Shunsuke| Shirakawa, Yasuhiro| Maeda, Naoaki| Ohara, Toshiaki| Noma, Kazuhiro| Sakurama, Kazufumi| Yanai, Hiroyuki| Yamatsuji, Tomoki| Naomoto, Yoshio| Fujiwara, Toshiyoshi|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/45273
FullText URL 65_2_135.pdf
Author Matsuo, Toshihiko| Himei, Kengo| Ishii, Keita| Ichimura, Kouichi| Yanai, Hiroyuki| Nose, Soichiro| Mimura, Tetsushige|
Abstract An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cerebellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
Keywords retinal (papillary, optic disc) hemangioma von Hippel-Lindau disease pheochromocytoma pancreatic neuroendocrine tumor external beam radiation (radiotherapy)
Amo Type Case Report
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 135
End Page 141
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519372
Web of Sience KeyUT 000289818800010
JaLCDOI 10.18926/AMO/31848
FullText URL fulltext.pdf
Author Iishi, Tatsuhiko| Hiraki, Takao| Mimura, Hidefumi| Gobara, Hideo| Kurose, Taichi| Fujiwara, Hiroyasu| Sakurai, Jun| Yanai, Hiroyuki| Yoshino, Tadashi| Kanazawa, Susumu|
Abstract <p>The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion;group 2 (n5) zones were created by applying greater RF power without saline infusion;and group 3 (n9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1ml before RFA, followed by continuous administration at a rate of 1ml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p0.059) and group 2 (p0.053). Group 3 showed significantly longer RF application time than group 2 (p0.004) and significantly greater maximum RF power than group 1 (p0.001) and group 2 (p0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858mm3, p0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878mm3, p0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.</p>
Keywords radiofrequency ablation lung experimental study
Amo Type Original Article
Published Date 2009-06
Publication Title Acta Medica Okayama
Volume volume63
Issue issue3
Publisher Okayama University Medical School
Start Page 137
End Page 144
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19571900
Web of Sience KeyUT 000267388200003
JaLCDOI 10.18926/AMO/31108
FullText URL fulltext.pdf
Author Miyatani, Katsuya| Takahashi, Kiyoshi| Yanai, Hiroyuki| Yoshino, Tadashi| Akagi, Tadaatsu|
Abstract <p>Previously, we reported that interleukin-2 (IL-2)-stimulated helper T cells produced an unknown soluble factor which induced dendritic cell-like differentiation in primary cultures of monocytic leukemia cells and we referred to this factor as dendritic cell differentiation factor (DCDF). In this study, we attempted to purify and characterize DCDF and investigated its biological effect on normal human monocytes. Gel filtration chromatography indicated that the molecular weight of DCDF is approximately 30-35 kDa. Chromatofocusing indicated that the isoelectric point of DCDF is approximately 5.0. DCDF, partially purified by subsequent gel filtration, chromatofocusing, and hydrophobic chromatography, significantly enhanced the HLA-DR expression of normal human monocytes and a human monocytic leukemia cell line, THP-1. This biological activity was not neutralized by any known antibodies to human cytokines. DCDF significantly amplified the T-cell stimulatory activity of monocytes in the allogeneic mixed leukocyte reaction (MLR). Moreover, DCDF significantly enhanced IL-1 beta and IL-6 production by monocytes in a dose-dependent manner. These results suggest that DCDF is a novel human cytokine which stimulates the accessory cell function of monocytes.</p>
Keywords dendritic cell differentiation protein purification cytokine
Amo Type Article
Published Date 1994-04
Publication Title Acta Medica Okayama
Volume volume48
Issue issue2
Publisher Okayama University Medical School
Start Page 67
End Page 72
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8042536
Web of Sience KeyUT A1994NJ77500001
JaLCDOI 10.18926/AMO/30764
FullText URL fulltext.pdf
Author Ino, Hideo| Hayashi, Kazuhiko| Yanai, Hiroyuki| Teramoto, Norihiro| Koirala, Tirtha Raj| Chen, Hong-Li| Oka, Takashi| Yoshino, Tadashi| Takahashi, Kiyoshi| Akagi, Tadaastu|
Abstract <p>A simian cell line, Si-IIA, harboring Epstein-Barr-virus (EBV) -related herpesvirus (Si-IIA-EBV), produces malignant lymphoma in rabbits when administered by intravenous inoculation. In this study, we analyzed the Si-IIA-EBV genome and compared it with human EBV and herpesvirus macaca fascicularis 1 (HVMF 1 ), which is associated with B-cell lymphoma developing in SIV-infected immunosuppressed monkeys. DNA from Si-IIA-EBV was amplified by the polymerase chain reaction using three different primer pairs complementary to human EBV (B95-8) DNA; two of the primer pairs covered part of the long internal repeat 1 region (IR 1) and the third covered part of the BRRF 1 region. Direct sequencing of the three PCR products revealed that Si-IIA-EBV DNA had about 82% nucleotide homology to the human EBV DNA in all three regions and 92.4% homology to HVMF1 in the IR1 region. The blotting pattern by Southern blot analysis was different between Si-IIA-EBV and human EBV.</p>
Keywords Epstein-Barr virus HVMF 1 lymphoma ?monkey cell line PCR
Amo Type Article
Published Date 1997-08
Publication Title Acta Medica Okayama
Volume volume51
Issue issue4
Publisher Okayama University Medical School
Start Page 207
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9284968
Web of Sience KeyUT A1997XU03200004
JaLCDOI 10.18926/AMO/30509
FullText URL fulltext.pdf
Author Yanai, Hiroyuki| Yoshino, Tadashi| Takahashi, Kiyoshi| Ninomiya, Yoshifumi| Akagi, Tadaatsu|
Abstract <p>Circulating hepatitis C virus (HCV) particles can be fractionated by means of differential flotation centrifugation. It is reported that in the bottom fraction HCV is in the form immune complexes, whereas in the top, it is free of antibodies. We evaluated the significance of circulating complex and free HCV in chronic hepatitis C, and assessed the relationship in terms of the response to interferon (IFN) therapy. We examined sera before, just after, and 1 year after administering IFN to 18 patients with chronic hepatitis C, 10 of whom responded (group CR), and 8 did not (group NR). The amounts of virus were similar between both groups before therapy. After differential flotation centrifugation with 1.063 g/ml of NaCl, the top and bottom fractions were assayed for HCV RNA. Before therapy, HCV RNA was detected in the top fraction in 1 of 10 in group CR, and in 6 of 8 in group NR (P &#60; 0.05, chi-square test). HCV RNA was positive in the bottom fraction of all samples. In a follow-up study of group NR, HCV RNA was detected in the top fraction in 3 of 8 just after IFN therapy, and in 7 of 8 after 1 year. This study suggests that the presence of HCV in the top fraction can predict a poor response to IFN therapy.</p>
Keywords IL-2R ??chain phorbol ester monocyte differentiation protein kinase
Amo Type Article
Published Date 1996-06
Publication Title Acta Medica Okayama
Volume volume50
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 150
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8805853
Web of Sience KeyUT A1996UU60400005
Author Yanai, Hiroyuki|
Published Date 1983-02-28
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue1-2
Content Type Journal Article
Author Matsuoka, Junji| Tabuchi, Yoko| Ono, Ryoko| Imada, Takako| Umeoka, Tatsuo| Watanabe, Naoki| Motoki, Takayuki| Matsukawa, Hiroyosi| Naomoto, Yoshio| Tanaka, Noriaki| Yanai, Hiroyuki| Omori, Masako|
Published Date 2006-09-01
Publication Title 岡山医学会雑誌
Volume volume118
Issue issue2
Content Type Journal Article
Author Matsuoka, Junji| Tabuchi, Yoko| Ito, Mitsuya| Ono, Ryoko| Imada, Takako| Motoki, Takayuki| Matsukawa, Hiroyosi| Ohmori, Masako| Yanai, Hiroyuki| Naomoto, Yoshio| Tanaka, Noriaki|
Published Date 2006-09-01
Publication Title 岡山医学会雑誌
Volume volume118
Issue issue2
Content Type Journal Article
Author 柳井 広之|
Published Date 1996-03-31
Publication Title
Content Type Thesis or Dissertation