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ID 16835
Eprint ID
16835
FullText URL
Thumnail 91_453.pdf 386 KB
Title Alternative
Illudin S; a possible new type inhibitor of RNA synthesis, and analysis of its action mechanism
Author
Itano, Toshifumi
Abstract
Illudin S primarily and specificially inhibited RNA synthesis at a concentration of 1-10ng/ml of culture medium in the early period of G(1)-S phase transition as well as in S phase in a growing medium. DNA synthesis in S phase and cell proliferation were inhibited as secondary events. The inhibitory effects on RNA synthesis were only manifested in intact cell systems, not in cell-free ones. DNA replication in a nucleotide-permeable cell system was completely insensitive to Illudin S. Protein synthesis in intact cell systems was not inhibited by Illudin S. Illudin S should prove useful in the analysis of the mechanism of G(l)-S phase transition in the cell cycle; especially in the elucidation of specific kinds of RNA required for initiation of DNA replication.
Keywords
Illudin S
RNA合成
DNA合成
細胞増殖
線維芽細胞
Published Date
1979-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
453
End Page
460
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/3-4/91_3-4_453/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma