Author Joja, Ikuo| Hiraki, Yoshio| Ueda, Hiroyuki| Nakamura, Tetsuya| Yamamoto, Yoshio| Kaji, Mitumasa| Togami, Izumi| Niiya, Harutaka| Shirakami, Toshiaki| Hayashi, Hidehiro| Kimoto, Shin| Aono, Kaname| Sugita, Katsuhiko| Ueoka, Hiroshi| Ohnoshi, Taisuke| Kimura, Ikuro|
Published Date 1985-10-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue9-10
Content Type Journal Article
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Ohtani, Jun| Kitani, Hikaru| Matsuka, Yohko| Kimura, Ikuro| Akagi, Katsumi| Townley Robert G.|
Published Date 1983-06-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue5-6
Content Type Journal Article
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Nakago, Jitsuo| Morinaga, Hiroshi| Ohtani, Jun| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Published Date 1984-04-30
Publication Title 岡山医学会雑誌
Volume volume96
Issue issue3-4
Content Type Journal Article
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kobashi, Hidetoshi| Shioda, Yutaro| Matsuka, Yoko| Takeyama, Hiroyasu| Harada, Hiroshi| Tada, Shinya| Kimura, Ikuro|
Published Date 1983-12-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue11-12
Content Type Journal Article
Author Kimura, Ikuro| Tanizaki, Yoshiro| Sato, Suichi| Saito, Katsuyoshi| Takahashi, Kiyoshi| Ueda, Nobuo| Ono, Hatsuko| Moritani, Yoshiaki|
Published Date 1975-02-28
Publication Title 岡山医学会雑誌
Volume volume87
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1975-10-30
Publication Title 岡山医学会雑誌
Volume volume87
Issue issue9-10
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1976-02-28
Publication Title 岡山医学会雑誌
Volume volume88
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro| Moritani, Yoshiaki| Yamana, Masatoshi| Onoshi, Taisuke| Takata, Hiromi| Shirai, Koichi| Nishizaki, Yoshitomo| Tanizaki, Yoshiro| Kunimasa, Ikuya| Nishishita, Akira| Takano, Junko| Kawahara, Hiroshi|
Published Date 1971-04-30
Publication Title 岡山医学会雑誌
Volume volume83
Issue issue3-4
Content Type Journal Article
Author Kimura, Ikuro| Moritani, Yoshiaki| Tanizaki, Yoshiro| Saito, Katsuyoshi| Takahashi, Kiyoshi|
Published Date 1972-02-28
Publication Title 岡山医学会雑誌
Volume volume84
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro| Kibata, Masayoshi| Hanzawa, Atsumasa| Moritani, Yoshiaki| Onoshi, Taisuke| Takata, Hiromi| Nishizaki, Yoshitomo| Kunimasa, Ikuya| Nishishita, Akira| Tanizaki, Yoshiro| Takano, Junko|
Published Date 1970-12-30
Publication Title 岡山医学会雑誌
Volume volume82
Issue issue11-12
Content Type Journal Article
Author Hiraki, Kiyoshi| Kimura, Ikuro| Ota, Zensuke| Asano, Kenwo| Kageyama, Hiroshi| Shibuya, Koichi| Kotani, Hidenari| Matsuura, Ryozo| Tsuchida, Junichiro| Sezaki, Tatsuo| Hiraoka, Toshinobu| Himei, Hajime| Moritani, Yoshiaki| Yamana, Masatoshi|
Published Date 1963-03-30
Publication Title 岡山医学会雑誌
Volume volume75
Issue issue1-3
Content Type Journal Article
Author Kitani, Hikaru| Mifune, Takashi| Kawauchi, Kazuhisa| Okazaki, Morihiro| Tanizaki, Yoshiro| Takahashi, Hisaho| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro| Ishii, Akira|
Published Date 1990-10
Publication Title 岡山医学会雑誌
Volume volume102
Issue issue9-10
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Okamoto, Tadashi| Okano, Takuya| Saito, Tetsuro| Kimura, Ikuro| Tanaka, Motosuke| Yamashita, Miyokichi| Shindo, Tsutomu| Kuninobu, Masuhiro| Tominaga, Hiroshi| Ishida, Toyoshige| Takeda, Toshiteru| Numamoto, Tetsuro| Kotakemori, Yasuo| Nakayama, Akio| Hoen, Sachihiko|
Published Date 1954-12-30
Publication Title 岡山医学会雑誌
Volume volume66
Issue issue12
Content Type Journal Article
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Soda, Ryo| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue5-6
Content Type Journal Article
JaLCDOI 10.18926/11822
Title Alternative Sarcoidosis and Propionibacterium acnes
FullText URL 003_019_036.pdf
Author Nakata, Yasunari| Kataoka, Mikio| Kimura, Ikuro|
Abstract Although there have been numerous reports on the isolation of bacteria, fungus, and aetiological agents of chemical substances from specimens of patients with sarcoidosis, none of them have been substantiated. In any event, an understanding of the pathogenesis of pulmonary sarcoid is intimately linked to that of the processes involved in the accumulation of T-cells in the lower respiratory tract of individuals with sarcoidosis. Propionibacterium acnes was isolated at high rates and in high concetrations from lymph nodes in patients with sarcoidosis. However, the precise mechanism of granuloma formation and immunomodulation by P. acnes has not been elucidated yet. In patients with sarcoidosis, it was found that the high levels of interleukin-2 (IL-2) released from alveolar lymphocytes as well as interleukin-1, tumor necrosis factor (TNF) and interleukin-6 (IL-6) released from alveolar macrophages were stimulated by P. acnes. These cytokines (mainly IL-2), released by P. acnes in large quantities, play a major role in the compartmentalization of the T-cell population in the lung and lead to the formation of an alveolitis and granuloma in the lung parenchyma of patients with sarcoidosis. This paper focuses primarily on the role of the cytokine network in the pulmonary mononuclear cells in the lung of patients with sarcoidosis.
Keywords sarcoidosis macrophage T-cell interleukin-2 Propionibacterium acnes
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1993-01-31
Volume volume3
Start Page 19
End Page 36
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313339
JaLCDOI 10.18926/11579
Title Alternative 気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について
FullText URL 061_016_022.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Komagoe, Haruki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions.
Abstract Alternative 気管支喘息27例および健康人7名を対象に,抗ヒトIgEおよびカルシウムイオノフォァA23187(CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は,非アトピー型喘息に比べ,アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は,非使用例に比べ,ステロイド依存性喘息において低い傾向がみられた。また,年齢では39才以下,発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は,低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には,抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より,好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。
Keywords Histamine release (ヒスタミン遊離) Basophils (好塩基球) Anti-lgE (抗ヒトIgE) Calcium ionophore A 23187 (カルシウムイオノフォァA23187) Bronchial asthma (気管支喘息)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 16
End Page 22
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002313673
JaLCDOI 10.18926/11625
Title Alternative Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. -
FullText URL 061_007_015.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例(延べ90例)を対象に,その背景因子,臨床的特徴,および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは,気管支喘息65例,肺気腫4例,肺結核症4例,アレルギー性肉芽腫性血管炎3例,閉塞性細気管支炎3例,気管支拡張症2例,慢性気管支炎2例,過敏性肺臓炎2例であり,昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち,温泉療法を受けた症例は63例(74.1%)であった。(3)温泉療 法を受けた症例の地域分布では,鳥取県からの入院症例51例では32例(62.7%)であり,同様に岡山県からの入院症例20例では19例(95.0%),その他の県からの入院症例14例で12例(85.7%)であった。4.温泉療法の臨床効果は,気管支喘息では51例中著効14例,有効27例,やや有効8例,無効2例であり,明らかな有効例は41例(80.3%)であった。
Abstract Alternative Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis.
Keywords 気管支喘息 (Bronchial asthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 慢性気管支炎 (Chronic bronchitis) 血清コーチゾール値 (Serum cortisol level) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 7
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313875