Author Joja, Ikuo| Hiraki, Yoshio| Ueda, Hiroyuki| Nakamura, Tetsuya| Yamamoto, Yoshio| Kaji, Mitumasa| Togami, Izumi| Niiya, Harutaka| Shirakami, Toshiaki| Hayashi, Hidehiro| Kimoto, Shin| Aono, Kaname| Sugita, Katsuhiko| Ueoka, Hiroshi| Ohnoshi, Taisuke| Kimura, Ikuro|
Published Date 1985-10-30
Publication Title 岡山医学会雑誌
Volume volume97
Issue issue9-10
Content Type Journal Article
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Ohtani, Jun| Kitani, Hikaru| Matsuka, Yohko| Kimura, Ikuro| Akagi, Katsumi| Townley Robert G.|
Published Date 1983-06-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue5-6
Content Type Journal Article
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Nakago, Jitsuo| Morinaga, Hiroshi| Ohtani, Jun| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Published Date 1984-04-30
Publication Title 岡山医学会雑誌
Volume volume96
Issue issue3-4
Content Type Journal Article
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kobashi, Hidetoshi| Shioda, Yutaro| Matsuka, Yoko| Takeyama, Hiroyasu| Harada, Hiroshi| Tada, Shinya| Kimura, Ikuro|
Published Date 1983-12-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue11-12
Content Type Journal Article
Author Kimura, Ikuro| Tanizaki, Yoshiro| Sato, Suichi| Saito, Katsuyoshi| Takahashi, Kiyoshi| Ueda, Nobuo| Ono, Hatsuko| Moritani, Yoshiaki|
Published Date 1975-02-28
Publication Title 岡山医学会雑誌
Volume volume87
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1975-10-30
Publication Title 岡山医学会雑誌
Volume volume87
Issue issue9-10
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1976-02-28
Publication Title 岡山医学会雑誌
Volume volume88
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro| Moritani, Yoshiaki| Yamana, Masatoshi| Onoshi, Taisuke| Takata, Hiromi| Shirai, Koichi| Nishizaki, Yoshitomo| Tanizaki, Yoshiro| Kunimasa, Ikuya| Nishishita, Akira| Takano, Junko| Kawahara, Hiroshi|
Published Date 1971-04-30
Publication Title 岡山医学会雑誌
Volume volume83
Issue issue3-4
Content Type Journal Article
Author Kimura, Ikuro| Moritani, Yoshiaki| Tanizaki, Yoshiro| Saito, Katsuyoshi| Takahashi, Kiyoshi|
Published Date 1972-02-28
Publication Title 岡山医学会雑誌
Volume volume84
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro| Kibata, Masayoshi| Hanzawa, Atsumasa| Moritani, Yoshiaki| Onoshi, Taisuke| Takata, Hiromi| Nishizaki, Yoshitomo| Kunimasa, Ikuya| Nishishita, Akira| Tanizaki, Yoshiro| Takano, Junko|
Published Date 1970-12-30
Publication Title 岡山医学会雑誌
Volume volume82
Issue issue11-12
Content Type Journal Article
Author Hiraki, Kiyoshi| Kimura, Ikuro| Ota, Zensuke| Asano, Kenwo| Kageyama, Hiroshi| Shibuya, Koichi| Kotani, Hidenari| Matsuura, Ryozo| Tsuchida, Junichiro| Sezaki, Tatsuo| Hiraoka, Toshinobu| Himei, Hajime| Moritani, Yoshiaki| Yamana, Masatoshi|
Published Date 1963-03-30
Publication Title 岡山医学会雑誌
Volume volume75
Issue issue1-3
Content Type Journal Article
Author Kitani, Hikaru| Mifune, Takashi| Kawauchi, Kazuhisa| Okazaki, Morihiro| Tanizaki, Yoshiro| Takahashi, Hisaho| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro| Ishii, Akira|
Published Date 1990-10
Publication Title 岡山医学会雑誌
Volume volume102
Issue issue9-10
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Okamoto, Tadashi| Okano, Takuya| Saito, Tetsuro| Kimura, Ikuro| Tanaka, Motosuke| Yamashita, Miyokichi| Shindo, Tsutomu| Kuninobu, Masuhiro| Tominaga, Hiroshi| Ishida, Toyoshige| Takeda, Toshiteru| Numamoto, Tetsuro| Kotakemori, Yasuo| Nakayama, Akio| Hoen, Sachihiko|
Published Date 1954-12-30
Publication Title 岡山医学会雑誌
Volume volume66
Issue issue12
Content Type Journal Article
JaLCDOI 10.18926/19662
Title Alternative Effect of aging on pancreatic exocrine function -Aging and fecal chymotrypsin activity-
FullText URL 057_024_028.pdf
Author Matsumoto, Shuji| Harada, Hideo| Ochi, Koji| Takeda, Masahiko| Tanaka, Juntaro| Morinaga, Hiroshi| Yoshida, Mitsuo| Kimura, Ikuro|
Abstract 膵外分泌機能に及ぼす加齢の影響を検討する目的で,健常人43名,非膵疾患患者41名,老人ホーム入居者39名を対象として比色法により糞便中キモトリプシン活性(FCA)を測定し,以下の結論を得た。1)FCAは逐齢的に低下し,60歳以上は60歳未満より有意の低値を示した。しかし,分布図のretrospectiveな検討からは,膵外分泌機能の低下は,実際には65~70歳あたりから明らかになることが示唆された。2)FCAの正常下限値を14.5U/gに定めたが,高齢者の診療にあたってはこの正常値のみを根拠にして疾病の有無を判定すべきではない。3)老人ホーム入居者のFCAは特に低値を取ったがその主要因は高齢者が多いためと考えられた。
Abstract Alternative To examine the effect of aging on the pancreatic exocrine function, fecal chymotrypsin activity (FCA) was measured by the photometric method in 43 healthy controls, 39 controls in an old-age home and 41 patients with non-pancreatic diseases. Following conclusions were obtained. 1) Pancreatic exocrine function showed a significant decrease with aging as indicated by the present prospective study : ① a significantly lower FCA in the B group of 22 healthy controls (≧ 60 years of age) than the A group of 21 healthy controls (< 60 years of ago) ; ② significant correlationship between aging and FCA in the 43 healthy controls and also in the 41 patients with non-pancreatic diseases. 2) FCA in controls in an old-age home was especially low. Presumably it was due to their far-advanced aging. 3) The calculated lower limit of normal in FCA was 14.5U/g. However, the diagnosis of pancreatic diseases should not be coined solely on the basis of decreased FCA value.
Keywords 糞便中キモトリプシン活性 (Fecal chymotrypsin activity) 加齢 (Aging) 膵外分泌機能 (Pancreatic exocrine function) 膵 (Pancreas) 酵素 (Enzyme)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 24
End Page 28
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309096
JaLCDOI 10.18926/19669
Title Alternative Diagnosis of chronic pancreatitis
FullText URL 057_029_036.pdf
Author Takeda, Masahiko| Harada, Hideo| Matsumoto, Shuji| Ochi, Koji| Tanaka, Juntaro| Yoshida, Mitsuo| Oka, Hiroo| Miyake, Hirofumi| Kimura, Ikuro|
Abstract 近年,各種膵疾患に対する検査法の発達には目を見張るものがあるが,実際の運用にあたっては各検査法の適応,限界,組合わせおよび実施する順序等に迷うことが少なくない。本研究では,最近我々が経験した慢性膵炎Ⅰ群116例の診断過程を振り返ることにより,慢性膵炎の診断における理想的な検査法の組合わせとそれぞれの役割を検討し,同時に診断名のみならず病態と病期が容易に理解できる表現方法を提案した。画像診断法,膵外分泌機能検査法(EX),膵内分泌機能検査法(EN)を比較検討し,以下の結果を得た。①画像診断法は必須である。②内視鏡的逆行性膵胆管造影(ERCP)を軸とした腹部超音波検査(US)あるいは腹部CTスキャン(CT)の組合わせは欠くことができない。③EXもまた必須の検査法である。④ENは慢性膵炎の診断に必要不可欠ではないが,治療方針を決めるうえで重要である。⑤純粋膵液(PPJ)の生化学的検査と組織化学的検査は膵炎の診断と病態生理の解明に重要である。⑥PPJ中の細胞診は慢性膵炎に合併した膵癌の検索に有用である。⑦以下に示すような診断の記載方法を提案した。"Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)"。
Abstract Alternative Endoscopic retrograde cholangiopancreatography (ERCP), ultrasonography (US), computed tomography (CT), exocrine pancreatic function test (EX), endocrine pancreatic function test (EN), and analysis of pure pancreatic juice (PPJ) are currently available for the investigation of pancreatic diseases. The purpose of the present study is to evaluate the roles and preferable combinations of these tests in the diagnosis of chronic pancreatitis and then to propose a way to describe the results of the tests along with diagnosis for a better understanding of the disease process. Comparative studies of imaging, EX and EN led to the following conclusions. 1) imaging procedures (ERCP, US and CT) are mandatory, partly because they were frequently the test that showed diagnostic changes and partly because they often gave key information for operative treatment. Among the imaging procedures, ERCP combined with US and/or CT is mandatory because these combinations alone can reveal detailes of structural changes attendant on chronic pancreatitis. 2) EX is also mandatory, because it was occasionally the only test that showed diagnostic changes and partly because it often gave important information for medical treatment. 3) EN is also important, not because it was indispensable for detecting chronic pancreatitis, but because it often gave important information for medical treatment. For btter understanding of the disease process as well as diagnosis, we propose, as suggested by Seligson, that the test used for the establishment of the diagnosis and the degree as well as extent of abnormalities. An example is "Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)". This attitude will lead to a more rational approach to both diagnosis and treatment.
Keywords 慢性膵炎 (chronic pancreatitis) 画像診断 (imaging diagnosis) PS試験 (pure pancreatic juice) 純粋膵液(PPJ) (Pancreozymin-Secretin test) 内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP))
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 29
End Page 36
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309023
JaLCDOI 10.18926/11822
Title Alternative Sarcoidosis and Propionibacterium acnes
FullText URL 003_019_036.pdf
Author Nakata, Yasunari| Kataoka, Mikio| Kimura, Ikuro|
Abstract Although there have been numerous reports on the isolation of bacteria, fungus, and aetiological agents of chemical substances from specimens of patients with sarcoidosis, none of them have been substantiated. In any event, an understanding of the pathogenesis of pulmonary sarcoid is intimately linked to that of the processes involved in the accumulation of T-cells in the lower respiratory tract of individuals with sarcoidosis. Propionibacterium acnes was isolated at high rates and in high concetrations from lymph nodes in patients with sarcoidosis. However, the precise mechanism of granuloma formation and immunomodulation by P. acnes has not been elucidated yet. In patients with sarcoidosis, it was found that the high levels of interleukin-2 (IL-2) released from alveolar lymphocytes as well as interleukin-1, tumor necrosis factor (TNF) and interleukin-6 (IL-6) released from alveolar macrophages were stimulated by P. acnes. These cytokines (mainly IL-2), released by P. acnes in large quantities, play a major role in the compartmentalization of the T-cell population in the lung and lead to the formation of an alveolitis and granuloma in the lung parenchyma of patients with sarcoidosis. This paper focuses primarily on the role of the cytokine network in the pulmonary mononuclear cells in the lung of patients with sarcoidosis.
Keywords sarcoidosis macrophage T-cell interleukin-2 Propionibacterium acnes
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1993-01-31
Volume volume3
Start Page 19
End Page 36
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313339
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Soda, Ryo| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue5-6
Content Type Journal Article