Author Okamoto, Tadashi| Okano, Takuya| Saito, Tetsuro| Kimura, Ikuro| Tanaka, Motosuke| Yamashita, Miyokichi| Shindo, Tsutomu| Kuninobu, Masuhiro| Tominaga, Hiroshi| Ishida, Toyoshige| Takeda, Toshiteru| Numamoto, Tetsuro| Kotakemori, Yasuo| Nakayama, Akio| Hoen, Sachihiko|
Published Date 1954-12-30
Publication Title 岡山医学会雑誌
Volume volume66
Issue issue12
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1957-07-31
Publication Title 岡山医学会雑誌
Volume volume69
Issue issue7
Content Type Journal Article
Author Hiraki, Kiyoshi| Kimura, Ikuro| Ota, Zensuke| Asano, Kenwo| Kageyama, Hiroshi| Shibuya, Koichi| Kotani, Hidenari| Matsuura, Ryozo| Tsuchida, Junichiro| Sezaki, Tatsuo| Hiraoka, Toshinobu| Himei, Hajime| Moritani, Yoshiaki| Yamana, Masatoshi|
Published Date 1963-03-30
Publication Title 岡山医学会雑誌
Volume volume75
Issue issue1-3
Content Type Journal Article
Author Kimura, Ikuro| Kibata, Masayoshi| Hanzawa, Atsumasa| Moritani, Yoshiaki| Onoshi, Taisuke| Takata, Hiromi| Nishizaki, Yoshitomo| Kunimasa, Ikuya| Nishishita, Akira| Tanizaki, Yoshiro| Takano, Junko|
Published Date 1970-12-30
Publication Title 岡山医学会雑誌
Volume volume82
Issue issue11-12
Content Type Journal Article
Author Kimura, Ikuro| Moritani, Yoshiaki| Yamana, Masatoshi| Onoshi, Taisuke| Takata, Hiromi| Shirai, Koichi| Nishizaki, Yoshitomo| Tanizaki, Yoshiro| Kunimasa, Ikuya| Nishishita, Akira| Takano, Junko| Kawahara, Hiroshi|
Published Date 1971-04-30
Publication Title 岡山医学会雑誌
Volume volume83
Issue issue3-4
Content Type Journal Article
Author Kimura, Ikuro| Moritani, Yoshiaki| Tanizaki, Yoshiro| Saito, Katsuyoshi| Takahashi, Kiyoshi|
Published Date 1972-02-28
Publication Title 岡山医学会雑誌
Volume volume84
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro| Tanizaki, Yoshiro| Sato, Suichi| Saito, Katsuyoshi| Takahashi, Kiyoshi| Ueda, Nobuo| Ono, Hatsuko| Moritani, Yoshiaki|
Published Date 1975-02-28
Publication Title 岡山医学会雑誌
Volume volume87
Issue issue1-2
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1975-10-30
Publication Title 岡山医学会雑誌
Volume volume87
Issue issue9-10
Content Type Journal Article
Author Kimura, Ikuro|
Published Date 1976-02-28
Publication Title 岡山医学会雑誌
Volume volume88
Issue issue1-2
Content Type Journal Article
JaLCDOI 10.18926/21145
Title Alternative Pulmonary lesions in rheumatoid arthritis-survey of chest radiographs in patients admitted with rheumatoid arthritis during last ten years
FullText URL pitsr_051_001_015.pdf
Author Tanizaki, Yoshiro| Oda, Yasuhiro| Tanaka, Juntaro| Komagoe, Haruki| Takasugi, Kiyoshi| Morinaga, Hiroshi| Harada, Hiroshi| Kimura, Ikuro|
Abstract Chest radiographs were examined in 147 patients with rheumatoid arthritis who were admitted at the Department ofInternal Medicine, Okayama University, Misasa Medical Branch during last ten years. The results were as follows. 1) Diffuse micronodular shadow on chest radiographs was shown in eighty nine out of 147 cases (60.5%), although the incidence of micronodular shadow was 47.3% in the other types except type 1, demonstrating the shadow limitted in the part of lower lung fields. The incidence in type 2 and 3, revealing micronodular shadow distributed over lung fields, was 22.4%. 2) The incidence of micronodular shadow was more frequently found in females than in males. The results obtained here was different from those previously reported. 3) The cases with type 2 and 3 tended to demonstrate a long duration of the desease, acceleration of ESR, positive rheumatoid factors, and elevation of serum γ-globulin and IgG levels, compared with the other types and cases without radiological findings. 4) Pulmonary lesions induced by treatment of gold or penicillamine were not recognized, except one suspected case with gold therapy.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 1
End Page 15
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310957
JaLCDOI 10.18926/21134
Title Alternative Studies on Rat Peritoneal Mast Cells 1. Purification of Mast Cells From Rat Peritoneal Cavity
FullText URL pitsr_052_023_028.pdf
Author Tanizaki, Yoshiro| Tanaka, Juntaro| Komagoe, Haruki| Morinaga, Hiroshi| Kishimoto, Takumi| Kimura, Ikuro| Townley Robert G.|
Abstract To get a high recovery rate of mast cells from the rat peritoneal cavity, a new modified method was discussed using BSA density gradient. Three procedures, peritoneal lavage, washing of peritoneal cells and purification by BSA, were tested in this study, and the numbers of total cells and mast cells in each procedure were calculated. The recovery rate was the highest in BSA density gradient purification of the cells washed once with low speed centrifugation. The recovery rate was 73.7% and the number of mast cells taken from one rat was approximately 1.5×10(6). The purity of the cells with this procedure was 95.0% (range from 93.0 to 96.0%).
Publication Title 岡山大学温泉研究所報告
Published Date 1982-03-25
Volume volume52
Start Page 23
End Page 28
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310940
JaLCDOI 10.18926/21135
Title Alternative Studies on Rat Peritoneal Mast Cells 2. Effect of BSA on Ca(2+) Uptake of Mast Cells
FullText URL pitsr_052_029_032.pdf
Author Tanizaki, Yoshiro| Tanaka, Juntaro| Komagoe, Haruki| Morinaga, Hiroshi| Kishimoto, Takumi| Kimura, Ikuro| Townley Robert G.|
Abstract To examine the effect of BSA on the cell surface of mast cells, the (45)Ca influx was observed in mast cells from actively sensitized rats and also in cells passively sensitized with IgE-containing serum before or after purification by BSA. The mast cells from actively sensitized rats showed a marked increase in the (45)Ca uptake with stimulation by ovalbumin. The value of (45)Ca uptake by the cells was 1495 ± 104 cpm / 10(5) cells. The uptake of (45)Ca by mast cells passively sensitized before or after separation through BSA was also increased in response to ovalbumin, although the degree of 45Ca uptake by the latter showed marked variation. These results may suggest that BSA affects mast cell surface when the cells are sensitized after separation by BSA.
Publication Title 岡山大学温泉研究所報告
Published Date 1982-03-25
Volume volume52
Start Page 29
End Page 32
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311041
JaLCDOI 10.18926/21119
Title Alternative 好塩基球からのヒスタミン遊離に関する研究. 2. ハウスダスト抗原および抗ヒトIgEによるヒスタミン遊離
FullText URL pitsr_053_029_033.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Mifune, Masaaki| Morinaga, Hiroshi| Kitani, Hikaru| Goda, Yoshinori| Tada, Shinya| Kimura, Ikuro|
Abstract IgE-mediated release of histamine from whole blood was examined in two healthy and four asthmatic subjects by dose-dependent fashion. The significantly increased amount of histamine was released from basophils of both healthy and asthmatic subjects by a limited concentration of anti-IgE. Antigen (house dust) caused histamine release only from basophils of asthmatics who are sensitive to house dust. Basophils from one patients with asthma released no significant amount of histamine by anti-IgE.
Abstract Alternative 好塩基球からのIgE-mediated histamine releaseの機序を,健康人(2名)および気管支喘息(4例)それぞれの代表例で比較検討した. 抗ヒトIgEの添加濃度別検討では,健康人および外因性喘息例いずれも有意のヒスタミン遊離の増加をしめしたが,Max. % histamine releaseをひきおこす抗ヒトIgEの濃度は比較的限られた範囲内にある傾向がみられた. 一方内因性喘息例では,いずれの抗ヒトIgE濃度でも有意のヒスタミン遊離はみられなかった. ハウスダスト抗原の添加濃度別検討では,ハウスダストが抗原である気管支喘息症例においてdose-dependentなヒスタミン遊離が観察されたが,使用された抗原濃度の範囲ではMax. % releaseをひきおこす至適濃度は明らかでなかった.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 29
End Page 33
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310980
JaLCDOI 10.18926/21121
Title Alternative Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases
FullText URL pitsr_053_045_049.pdf
Author Komagoe, Haruki| Sudo, Michiyasu| Okada, Chiharu| Tanizaki, Yoshiro| Morinaga, Hiroshi| Kitani, Hikaru| Goda, Yoshinori| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 45
End Page 49
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311040
JaLCDOI 10.18926/21118
Title Alternative 好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定
FullText URL pitsr_053_023_028.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Mifune, Masaaki| Morinaga, Hiroshi| Ohtani, Jun| Kitani, Hikaru| Goda, Yoshinori| Tada, Shinya| Kimura, Ikuro|
Abstract Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the method is useful for the diagnosis and study of allergy.
Abstract Alternative ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 23
End Page 28
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310945
JaLCDOI 10.18926/21120
Title Alternative Clinical effects of swimming training in a hot spring pool on bronchial asthma
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Murashima, Makoto| Okada, Chiharu| Morinaga, Hiroshi| Kobashi, Hidetoshi| Tada, Shinya| Kimura, Ikuro|
Abstract Five severe bronchial asthma patients with glucocorticoid therapy have had free swimming training in the hot spring pool at Misasa Medical Branch. The clinical effect of the swimming training was evaluated after 3 months' training. 1. A slight increase in pulse rate and blood pressure was observed immediately after 30 minutes, swimming, although no significant increase in the two parameters was shown 30 min. after the training. 2. No significant fall in ventilatory function tests such as % FVC, FEV(1.0)%, V(50) and V(25) was demonstrated following the swimming training in a hot spring pool. The results suggest that the free swimming training in a hot spring pool does not induce bronchoconstriction. 3. Clinical efficacy of the swimming training on bronchial asthma was evaluated according to a treatment score, an attack score and an asthmatic score. These scores were decreased during the swimming training. The results obtained in this study showed that free swimming training in a hot spring pool is one of the most suitable therapies for severe bronchial asthma patients.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 35
End Page 43
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40000321171
JaLCDOI 10.18926/21122
Title Alternative Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases
FullText URL pitsr_053_051_055.pdf
Author Sudo, Michiyasu| Komagoe, Haruki| Murashima, Makoto| Okada, Chiharu| Tanisaki, Yoshiro| Morinaga, Hiroshi| Shiota, Yutaro| Kimura, Ikuro|
Abstract Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 51
End Page 55
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310967
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Ohtani, Jun| Kitani, Hikaru| Matsuka, Yohko| Kimura, Ikuro| Akagi, Katsumi| Townley Robert G.|
Published Date 1983-06-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue5-6
Content Type Journal Article