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ID 13808
Eprint ID
13808
FullText URL
Thumnail 109_1.pdf 1.49 MB
Title Alternative
Cerebral dysgenesis and psychomotor retardation in neonatal epilepsy
Author
Oka, Eiji
Ohtahara, Shunsuke
Kawahara, Michiko
Sakae, Katsuyoshi
Hiraki, Yoshio
Abstract
A clinical and neuroradiological study was carried out to clarify the relationship among cerebral dysgenesis, psychomotor retardation and neonatal epilepsy. Twenty-one cases with epilepsy developed within four weeks after birth were selected among 770 in-patients with childhood epilepsy. They consisted of one benign familial neonatal convulsion, nine of early myoclonic encephalopathy, four of Ohtahara syndrome, six of symptomatic localizationrelated epilepsy, and one of undetermined epilepsy. Seven cases with non specific types of epilepsies were investigated in detail. They developed into four of frontal lobe epilepsy, one of temporal lobe epilepsy and one severe epilepsy with multiple independent spike foci. Psychomotor retardation was observed in six of seven cases, and cerebral dysgenesis was considered to be important as an etiological factor. Proton MR spectroscopy revealed the decrease in the ratio of N-acetylaspartate/choline in the area with heterotopic gray matter and in the side of hemimegalencephaly, contrasted with a contralateral area without lesions. These findings can be inferred to reflect the decreased numbers of neuronal cell population or reduced metabolism in the lesions.
Keywords
新生児期
局在関連性てんかん
心身障害
脳形成障害
MR スペクトロスコピー
Note
原著
Published Date
1997-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume109
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1
End Page
6
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/109/1-2/109_1-2_1/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma