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ID 13219
Eprint ID
13219
FullText URL
Thumnail 119_253.pdf 499 KB
Title Alternative
Apoe+/-ldlr+/- mice as a useful model to evaluate accelerated atherogenesis by Helicobacter pylori infection
Author
Cui, Jinhua
Abstract
Atherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis.
Keywords
動脈硬化 (atherosclerosis)
ヘリコバクター・ピロリ (Helicobacter pylori)
熱ストレスタンパク60 (heat shock protein 60)
Tリンパ球 (T-lymphocytes)
apoe+/-ldlr+/-ヘテロダブルノックアウトマウス (apoe+/-ldlr+/- mice)
Note
原著
Published Date
2008-01-04
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume119
Issue
issue3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
253
End Page
260
ISSN
00301558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
DOI
Eprints Journal Name
joma