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ID 13722
Eprint ID
13722
FullText URL
Thumnail 108_139.pdf 1.52 MB
Title Alternative
Radioprotective effect of epinephrine as a vasoconstrictor in mouse oral mucosa and scalp
Author
Gao, Xianshu
Nakagawa, Tomio
Yamamoto, Michinori
Sakae, Katsuyoshi
Shimizu, Mitsuharu
Niiya, Harutaka
Hiraki, Yoshio
Kawasaki, Shoji
Abstract
Epinephrine is the most widely used vasoconstrictive drug. However, its radioprotective potential has not yet been studied for radiation-induced mucositis and dermatitis. Other vasoconstrictive drugs induce a radioprotective effect, but are not used because of their severe side effects. We studied the radioprotective effect of epinephrine on the oral mucosa and scalp of the mice. The radiation dose was 20Gy in a single fraction to the head of the mouse. In the group treated with epinephrine ointment, secretion from the oral cavity was slight, body wieght loss was less and hair loss was observed in fewer cases compared to those in the group without of epinephrine ointment. The mechanism is thought to be related to oxygenation. Epinephrine causes vasoconstriction, therefore the blood supply is lowered and the oxygen concentration in the tissue decline. In conclusion, epinephrine is considered to have potential as a radioprotective ointment for mucous membranes and skin.
Keywords
エピネフリン
放射線防護剤
血管収縮
酸素効果
マウス粘膜皮膚
Note
原著
Published Date
1996-06-29
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume108
Issue
issue3-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
139
End Page
144
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_139/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma