Author Yoshimoto, Masaaki| Kataoka, Takahiro| Toyota, Teruaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-02-01
Publication Title Inflammation
Volume volume35
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2007-11-21
Publication Title Journal of Radiation Research
Volume volume48
Issue issue6
Content Type Journal Article
Author Toyota, Teruaki| Kataoka, Takahiro| Nishiyama, Yuichi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012
Publication Title Mediators of Inflammation
Volume volume2012
Content Type Journal Article
Author Nishiyama, Yuichi| Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Ishimori, Yuu| Yamaoka, Kiyonori|
Published Date 2012-05-29
Publication Title RADIOISOTOPES
Volume volume61
Issue issue5
Content Type Journal Article
JaLCDOI 10.18926/11694
Title Alternative 低線量放射線による抗酸化系の誘導と活性酸素病治療への応用の可能性
FullText URL 011_1_001_015.pdf
Author Yamaoka, Kiyonori|
Abstract We clarified that adequate oxygen stress induced by low dose radiation activates not only chemical biological protective function, such as induction of the synthesis of SOD, GPX and HSP70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose radiation can contribute to suppressing aging and to preventing or reducing active oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose radiation on the functions of the living body, including adaptive response.
Abstract Alternative ストレスなどの原因により生体内に生じた過剰な活性酸素は毒性を有し,これが細胞や組織障害につながり,老化や発癌など種々の病的状態を生み出している。これに対し,生体には活性酸素を消去したり,損傷を起こした分子を修復したりして結果的に生ずる障害を防御する機構がある。この抗酸化系防御機構は適度な酸化ストレス,即ち少量の活性酸素を生体内に発生させる環境下では,逆に活性化する可能性があり,注目されている。本総説は,少量活性酸素を生体内に生じさせる低線量放射線による抗酸化系防御機構の活性化の有無,生体膜の構造変化と機能活性に及ぼす作用,活性酸素病などの遠因となる生体内酸化傷害に及ぼす作用,さらにはラドン(主にα線放出)療法の適応症の機構について,今までに実施した我々の研究例を中心に総括し,評価するものである。即ち,マウス,ラットへのX線γ線照射実験やラビットへのラドン吸入実験により得られた成果例は次の通りである。低線量のX線,γ線照射やラドン吸入により,高線量放射線の場合とは逆に,週齢や臓器などに放射線感受性に違いはあるものの過酸化脂質量が減少し,膜流動性やATPase活性が若齢値に近づくように変化した。SOD,Cat,GPXなどの酵素活性が誘導合成に伴い亢進した。また,低線量放射線照射によりI型糖尿病症状,鉄あるいは四塩化炭素の誘導による肝障害,MPTPの誘導による脳障害などが緩和された。さらに,ラドン吸入により組織循環の促進や疼痛の緩和などが明らかになった。これらの知見より,低線量放射線は抗酸化系防御機構を活性化するとともに生体膜機能の若返り化を導くことが示唆できた。また,低線量放射線は糖尿病I型症状や肝,脳障害を緩和することから,活性酸素病の治療応用への可能性も示唆できた。さらに,ラドン療法の適応症の代表例である疼痛緩和などについても機構解明の一端がなされた。
Keywords antioxidant system (抗酸化系) low dose radiation (低線量放射線) radon inhalation (ラドン) active oxygen species related diseases (活性酸素病) adaptive response (適応応答 )
Publication Title 岡山大学医学部保健学科紀要
Published Date 2000-11-16
Volume volume11
Issue issue1
Start Page 1
End Page 15
ISSN 1345-0948
language 英語
File Version publisher
NAID 120002314000
Author Sakoda, Akihiro| Hanamoto, Katsumi| Ishimori, Yuu| Nagamatsu, Tomohiro| Yamaoka, Kiyonori|
Published Date 2008-06-23
Publication Title Radiation Measurements
Volume volume43
Issue issue1
Content Type Journal Article
Author Kobashi, Yusuke| Kataoka, Takahiro| Kanzaki, Norie| Ishida, Tsuyoshi| Sakoda, Akihiro| Tanaka, Hiroshi| Ishimori, Yuu| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Keywords Radon Thoron Oxidative stress Antioxidative function
Note This fulltext is available in Apr. 2021.|
Published Date 2020-04-22
Publication Title Radiation and Environmental Biophysics
Publisher Springer
ISSN 0301634X
NCID AA00800192
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32322961
DOI 10.1007/s00411-020-00843-0
Web of Science KeyUT 000528077400001
Related Url isVersionOf https://doi.org/10.1007/s00411-020-00843-0
Author Kataoka, Takahiro| Nishiyama, Yuichi| Yamato, Keiko| Teraoka, Junichi| Morii, Yuji| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-07-31
Publication Title Journal of Radiation Research
Volume volume53
Issue issue6
Content Type Journal Article
Author Kataoka, Takahiro| Yamato, Keiko| Nishiyama, Yuichi| Morii, Yuji| Etani, Reo| Takata, Yuji| Hanamoto, Katsumi| Kawabe, Atsuishi| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-10
Publication Title Renal Failure
Volume volume34
Issue issue9
Content Type Journal Article
Author Kataoka, Takahiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Mizuguchi, Yuko| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2009-09
Publication Title Journal of Clinical Biochemistry and Nutrition
Volume volume45
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/45267
FullText URL 65_2_91.pdf
Author Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori|
Abstract No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
Keywords tobacco radionuclides smoking intake radiation exposure
Amo Type Original Article
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 95
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519366
Web of Science KeyUT 000289818800004
Author Kataoka, Takahiro| Yamaoka, Kiyonori|
Published Date 2012-02-09
Publication Title ISRN Endocrinology
Volume volume2012
Content Type Journal Article