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ID 48968
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Author
Nishiyama, Yuichi
Yamato, Keiko
Teraoka, Junichi
Morii, Yuji
Sakoda, Akihiro
Ishimori, Yuu
Abstract
We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl(4))-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl(4)-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and α-tocopherol on CCl(4)-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl(4) after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or α-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl(4)-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or α-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl(4) alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl(4)-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or α-tocopherol due to the induction of anti-oxidative functions.
Keywords
Radon
ascorbic acid
α-tocopherol
antioxidant
hepatopathy
Published Date
2012-07-31
Publication Title
Journal of Radiation Research
Volume
volume53
Issue
issue6
Publisher
Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology
Start Page
830
End Page
839
ISSN
0449-3060
NCID
AA00705792
Content Type
Journal Article
Official Url
http://jrr.oxfordjournals.org/content/53/6/830
language
英語
Copyright Holders
Copyright © 2012 Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology
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Refereed
True
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